Drug-seeking Motivation Level in Male Rats Determines Offspring Susceptibility or Resistance to Cocaine-seeking Behaviour

Overview

Journal Nat Commun

Specialty Biology

Date 2017 May 31

PMID 28556835

Citations 38

Authors

Qiumin Le

Biao Yan

Xiangchen Yu

Yanqing Li

Haikun Song

Huiwen Zhu

Weiqing Hou

Dingailu Ma

Feizhen Wu

Yuqing Zhou

Lan Ma

Affiliations

Soon will be listed here.

Abstract

Liability to develop drug addiction is heritable, but the precise contribution of non-Mendelian factors is not well understood. Here we separate male rats into addiction-like and non-addiction-like groups, based on their incentive motivation to seek cocaine. We find that the high incentive responding of the F0 generation could be transmitted to F1 and F2 generations. Moreover, the inheritance of high incentive response to cocaine is contingent on high motivation, as it is elicited by voluntary cocaine administration, but not high intake of cocaine itself. We also find DNA methylation differences between sperm of addiction-like and non-addiction-like groups that were maintained from F0 to F1, providing an epigenetic link to transcriptomic changes of addiction-related signalling pathways in the nucleus accumbens of offspring. Our data suggest that highly motivated drug seeking experience may increase vulnerability and/or reduce resistance to drug addiction in descendants.

Citing Articles

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