Epigenetic Transgenerational Actions of Endocrine Disruptors

Overview

Journal Reprod Toxicol

Specialties Reproductive Medicine
Toxicology

Date 2010 Nov 9

PMID 21055462

Citations 82

Authors

Michael K Skinner

Mohan Manikkam

Carlos Guerrero-Bosagna

Affiliations

Soon will be listed here.

Abstract

Environmental factors have a significant impact on biology. Therefore, environmental toxicants through similar mechanisms can modulate biological systems to influence physiology and promote disease states. The majority of environmental toxicants do not have the capacity to modulate DNA sequence, but can alter the epigenome. In the event an environmental toxicant such as an endocrine disruptor modifies the epigenome of a somatic cell, this may promote disease in the individual exposed, but not be transmitted to the next generation. In the event a toxicant modifies the epigenome of the germ line permanently, then the disease promoted can become transgenerationaly transmitted to subsequent progeny. The current review focuses on the ability of environmental factors such as endocrine disruptors to promote transgenerational phenotypes.

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