Fractal Regulation in Temporal Activity Fluctuations: A Biomarker for Circadian Control and Beyond

Overview

Journal JSM Biomark

Publisher JSciMed Central

Date 2017 May 30

PMID 28553673

Citations 10

Authors

Peng Li

Tommy To

Wei-Yin Chiang

Carolina Escobar

Ruud M Buijs

Kun Hu

Affiliations

Soon will be listed here.

Abstract

Motor activity in humans and other animals possesses fractal temporal fluctuations that co-exists with circadian or daily activity rhythms. The perturbations in fractal activity patterns are often accompanied by altered circadian/daily rhythms. The goal of this study is to test whether fractal regulation in motor activity provides physiological information independent from 24-h/circadian rhythmicity. To achieve the goal, we studied locomotor activity recordings of rats with the lesion of the suprachiasmatic nucleus (SCN) that are known to have diminished circadian/daily activity rhythms and perturbed fractal regulation. By restricting feeding time (i.e., food was only availability in the dark period of the 12h: 12h light-dark cycles), we found that mean activity levels in these animals displayed significant 24-h rhythms. In contrast, the restricted feeding had no influences on the perturbed fractal regulation in these SCN-lesioned animals, i.e., activity fluctuations in these animals remained random over a wide range of time scales from 2-20h. Our results indicate that 24-h rhythm of food availability can restore/improve circadian/daily rhythms in the SCN-lesioned animals but not necessarily improve the disrupted fractal activity regulation in these animals. This study provides clear and direct evidence that fractal activity patterns offer complementary information about motor activity regulation at multiple time scales that is beyond 24-h rhythm control.

Citing Articles

Fractal motor activity during wakefulness and sleep: a window into depression recency and symptom recurrence.

Minaeva O, Riese H, Booij S, Lamers F, Giltay E, Scheer F Psychol Med. 2024; :1-9.

PMID: 39620467 PMC: 11650180. DOI: 10.1017/S0033291724002769.

Delineating cognitive resilience using fractal regulation: Cross-sectional and longitudinal evidence from the Rush Memory and Aging Project.

Li P, Gao C, Yu L, Gao L, Cai R, Bennett D Alzheimers Dement. 2024; 20(5):3203-3210.

PMID: 38497429 PMC: 11095481. DOI: 10.1002/alz.13747.

Dietary restriction modulates ultradian rhythms and autocorrelation properties in mice behavior.

Kembro J, Flesia A, Acosta-Rodriguez V, Takahashi J, Nieto P Commun Biol. 2024; 7(1):303.

PMID: 38461321 PMC: 10925031. DOI: 10.1038/s42003-024-05991-3.

Correlates of Person-Specific Rates of Change in Sensor-Derived Physical Activity Metrics of Daily Living in the Rush Memory and Aging Project.

Buchman A, Wang T, Oveisgharan S, Zammit A, Yu L, Li P Sensors (Basel). 2023; 23(8).

PMID: 37112493 PMC: 10142139. DOI: 10.3390/s23084152.

A dynamically coherent pattern of rhythms that matches between distant species across the evolutionary scale.

Kembro J, Flesia A, Nieto P, Caliva J, Lloyd D, Cortassa S Sci Rep. 2023; 13(1):5326.

PMID: 37005423 PMC: 10067965. DOI: 10.1038/s41598-023-32286-0.

References

Hu K, Meijer J, Shea S, vanderLeest H, Pittman-Polletta B, Houben T . Fractal patterns of neural activity exist within the suprachiasmatic nucleus and require extrinsic network interactions. PLoS One. 2012; 7(11):e48927. PMC: 3502397. DOI: 10.1371/journal.pone.0048927. View

Hu K, Harper D, Shea S, Stopa E, Scheer F . Noninvasive fractal biomarker of clock neurotransmitter disturbance in humans with dementia. Sci Rep. 2013; 3:2229. PMC: 3714649. DOI: 10.1038/srep02229. View

Hsieh W, Escobar C, Yugay T, Lo M, Pittman-Polletta B, Salgado-Delgado R . Simulated shift work in rats perturbs multiscale regulation of locomotor activity. J R Soc Interface. 2014; 11(96). PMC: 4032547. DOI: 10.1098/rsif.2014.0318. View

Hu K, Scheer F, Ivanov P, Buijs R, Shea S . The suprachiasmatic nucleus functions beyond circadian rhythm generation. Neuroscience. 2007; 149(3):508-17. PMC: 2759975. DOI: 10.1016/j.neuroscience.2007.03.058. View

Gu C, Coomans C, Hu K, Scheer F, Stanley H, Meijer J . Lack of exercise leads to significant and reversible loss of scale invariance in both aged and young mice. Proc Natl Acad Sci U S A. 2015; 112(8):2320-4. PMC: 4345576. DOI: 10.1073/pnas.1424706112. View

Stephan F, Zucker I . Circadian rhythms in drinking behavior and locomotor activity of rats are eliminated by hypothalamic lesions. Proc Natl Acad Sci U S A. 1972; 69(6):1583-6. PMC: 426753. DOI: 10.1073/pnas.69.6.1583. View

Goldberger A, Amaral L, Hausdorff J, Ivanov P, Peng C, Stanley H . Fractal dynamics in physiology: alterations with disease and aging. Proc Natl Acad Sci U S A. 2002; 99 Suppl 1:2466-72. PMC: 128562. DOI: 10.1073/pnas.012579499. View

Hu K, Riemersma-van der Lek R, Patxot M, Li P, Shea S, Scheer F . Progression of Dementia Assessed by Temporal Correlations of Physical Activity: Results From a 3.5-Year, Longitudinal Randomized Controlled Trial. Sci Rep. 2016; 6:27742. PMC: 4904193. DOI: 10.1038/srep27742. View

Moore R, Eichler V . Loss of a circadian adrenal corticosterone rhythm following suprachiasmatic lesions in the rat. Brain Res. 1972; 42(1):201-6. DOI: 10.1016/0006-8993(72)90054-6. View

10.

Witting W, Kwa I, Eikelenboom P, Mirmiran M, Swaab D . Alterations in the circadian rest-activity rhythm in aging and Alzheimer's disease. Biol Psychiatry. 1990; 27(6):563-72. DOI: 10.1016/0006-3223(90)90523-5. View

11.

Lo M, Chiang W, Hsieh W, Escobar C, Buijs R, Hu K . Interactive Effects of Dorsomedial Hypothalamic Nucleus and Time-Restricted Feeding on Fractal Motor Activity Regulation. Front Physiol. 2016; 7:174. PMC: 4870237. DOI: 10.3389/fphys.2016.00174. View

12.

Hu K, Ivanov P, Chen Z, Hilton M, Stanley H, Shea S . Non-random fluctuations and multi-scale dynamics regulation of human activity. Physica A. 2005; 337(1-2):307-18. PMC: 2749944. DOI: 10.1016/j.physa.2004.01.042. View

13.

Hu K, Ivanov P, Chen Z, Carpena P, Stanley H . Effect of trends on detrended fluctuation analysis. Phys Rev E Stat Nonlin Soft Matter Phys. 2001; 64(1 Pt 1):011114. DOI: 10.1103/PhysRevE.64.011114. View

14.

Hu K, van Someren E, Shea S, Scheer F . Reduction of scale invariance of activity fluctuations with aging and Alzheimer's disease: Involvement of the circadian pacemaker. Proc Natl Acad Sci U S A. 2009; 106(8):2490-4. PMC: 2650290. DOI: 10.1073/pnas.0806087106. View

15.

Pittman-Polletta B, Scheer F, Butler M, Shea S, Hu K . The role of the circadian system in fractal neurophysiological control. Biol Rev Camb Philos Soc. 2013; 88(4):873-94. PMC: 3766492. DOI: 10.1111/brv.12032. View

16.

Dos Santos Lima G, Lobao-Soares B, do Nascimento G, Franca A, Muratori L, Ribeiro S . Mouse activity across time scales: fractal scenarios. PLoS One. 2014; 9(9):e105092. PMC: 4183474. DOI: 10.1371/journal.pone.0105092. View