Functional Role of Mitochondria in Arrhythmogenesis

Overview

Journal Adv Exp Med Biol

Specialties Biology
General Medicine

Date 2017 May 29

PMID 28551788

Citations 39

Authors

Jessica Gambardella

Daniela Sorriento

Michele Ciccarelli

Carmine Del Giudice

Antonella Fiordelisi

Luigi Napolitano

Bruno Trimarco

Guido Iaccarino

Gaetano Santulli

Affiliations

Soon will be listed here.

Abstract

Growing evidence indicate that mitochondria play a functional role in arrhythmogenesis. We report here the molecular mechanisms underlying the action of these highly dynamic organelles in the regulation of cell metabolism, action potential and, overall, heart excitability. In particular, we examine the role of cardiac mitochondria in linking metabolism and cell excitability. The importance of the main mitochondrial channels is evaluated as well, including the recently identified calcium uniporter. Promises and pitfalls of potential therapeutic strategies targeting mitochondrial pathways are also assessed.

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