Decoding the Pluripotency Network: The Emergence of New Transcription Factors

Overview

Journal Biomedicines

Specialty Biomedical Engineering

Date 2017 May 27

PMID 28548056

Citations 10

Authors

Kai Chuen Lee

Wing Ki Wong

Bo Feng

Affiliations

Soon will be listed here.

Abstract

Since the successful isolation of mouse and human embryonic stem cells (ESCs) in the past decades, massive investigations have been conducted to dissect the pluripotency network that governs the ability of these cells to differentiate into all cell types. Beside the core Oct4-Sox2-Nanog circuitry, accumulating regulators, including transcription factors, epigenetic modifiers, microRNA and signaling molecules have also been found to play important roles in preserving pluripotency. Among the various regulations that orchestrate the cellular pluripotency program, transcriptional regulation is situated in the central position and appears to be dominant over other regulatory controls. In this review, we would like to summarize the recent advancements in the accumulating findings of new transcription factors that play a critical role in controlling both pluripotency network and ESC identity.

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