Altered Peripheral Profile of Blood Cells in Alzheimer Disease: A Hospital-based Case-control Study

Overview

Journal Medicine (Baltimore)

Specialty General Medicine

Date 2017 May 25

PMID 28538375

Citations 26

Authors

Si-Han Chen

Xian-Le Bu

Wang-Sheng Jin

Lin-Lin Shen

Jun Wang

Zheng-Qian Zhuang

Tao Zhang

Fan Zeng

Xiu-Qing Yao

Hua-Dong Zhou

Yan-Jiang Wang

Affiliations

Soon will be listed here.

Abstract

Alzheimer disease (AD) has been made a global priority for its multifactorial pathogenesis and lack of disease-modifying therapies. We sought to investigate the changes of profile of blood routine in AD and its correlation with the disease severity.In all, 92 AD patients and 84 age and sex-matched normal controls were enrolled and their profiles of blood routine were evaluated.Alzheimer disease patients had increased levels of mean corpuscular hemoglobin, mean corpuscular volume, red cell distribution width-standard deviation, mean platelet volume,and decreased levels of platelet distribution width, red blood cell, hematocrit, hemoglobin, lymphocyte, and basophil compared with normal controls.Alterations in quantity and quality of blood cells may be involved in the pathogenesis of AD and contribute to the disease progression.

Citing Articles

Targeting Shp2 as a therapeutic strategy for neurodegenerative diseases.

Pang J, Cen C, Tian Y, Cao X, Hao L, Tao X Transl Psychiatry. 2025; 15(1):6.

PMID: 39794316 PMC: 11724000. DOI: 10.1038/s41398-024-03222-1.

Increased Systemic Immune-Inflammation Index as a Novel Indicator of Alzheimer's Disease Severity.

Algul F, Kaplan Y J Geriatr Psychiatry Neurol. 2024; :8919887241280880.

PMID: 39271460 PMC: 11894901. DOI: 10.1177/08919887241280880.

Correlation analysis of peripheral platelet markers and disease phenotypes in Alzheimer's disease.

Fu J, Lai X, Zhang C, Wei Q, Chen X, Shang H Alzheimers Dement. 2024; 20(6):4366-4372.

PMID: 38713702 PMC: 11180931. DOI: 10.1002/alz.13841.

PEARL-Neuro Database: EEG, fMRI, health and lifestyle data of middle-aged people at risk of dementia.

Dzianok P, Kublik E Sci Data. 2024; 11(1):276.

PMID: 38453963 PMC: 10920678. DOI: 10.1038/s41597-024-03106-5.

Impact of stalling events on microcirculatory hemodynamics in the aged brain.

Jamshidi M, Ventimiglia T, Sudres P, Zhang C, Lesage F, Rooney W Microcirculation. 2024; 31(3):e12845.

PMID: 38265175 PMC: 11014774. DOI: 10.1111/micc.12845.

References

Siracusa M, Comeau M, Artis D . New insights into basophil biology: initiators, regulators, and effectors of type 2 inflammation. Ann N Y Acad Sci. 2011; 1217:166-77. PMC: 3076807. DOI: 10.1111/j.1749-6632.2010.05918.x. View

Song C, Vandewoude M, Stevens W, De Clerck L, Van der Planken M, Whelan A . Alterations in immune functions during normal aging and Alzheimer's disease. Psychiatry Res. 1999; 85(1):71-80. DOI: 10.1016/s0165-1781(98)00130-9. View

Zeng F, Zou H, Zhou H, Li J, Wang L, Cao H . The relationship between single nucleotide polymorphisms of the NTRK2 gene and sporadic Alzheimer's disease in the Chinese Han population. Neurosci Lett. 2013; 550:55-9. DOI: 10.1016/j.neulet.2013.06.061. View

Jayakumar R, Kusiak J, Chrest F, Demehin A, Murali J, Wersto R . Red cell perturbations by amyloid beta-protein. Biochim Biophys Acta. 2003; 1622(1):20-8. DOI: 10.1016/s0304-4165(03)00101-6. View

Yesil Y, Emin Kuyumcu M, Cankurtaran M, Uz B, Kara A, Kilic M . Increased mean platelet volume (MPV) indicating the vascular risk in Alzheimer's disease (AD). Arch Gerontol Geriatr. 2011; 55(2):257-60. DOI: 10.1016/j.archger.2011.09.016. View

Zhao Y, Zhao B . Oxidative stress and the pathogenesis of Alzheimer's disease. Oxid Med Cell Longev. 2013; 2013:316523. PMC: 3745981. DOI: 10.1155/2013/316523. View

Hachinski V, Iadecola C, Petersen R, Breteler M, Nyenhuis D, Black S . National Institute of Neurological Disorders and Stroke-Canadian Stroke Network vascular cognitive impairment harmonization standards. Stroke. 2006; 37(9):2220-41. DOI: 10.1161/01.STR.0000237236.88823.47. View

Zhou H, Deng J, Li J, Wang Y, Zhang M, He H . Study of the relationship between cigarette smoking, alcohol drinking and cognitive impairment among elderly people in China. Age Ageing. 2003; 32(2):205-10. DOI: 10.1093/ageing/32.2.205. View

Gu B, Huang X, Ou A, Rembach A, Fowler C, Avula P . Innate phagocytosis by peripheral blood monocytes is altered in Alzheimer's disease. Acta Neuropathol. 2016; 132(3):377-89. DOI: 10.1007/s00401-016-1596-3. View

10.

Chen H, Liu S, Ji L, Wu T, Ji Y, Zhou Y . Folic Acid Supplementation Mitigates Alzheimer's Disease by Reducing Inflammation: A Randomized Controlled Trial. Mediators Inflamm. 2016; 2016:5912146. PMC: 4909909. DOI: 10.1155/2016/5912146. View

11.

Fatima Shad K, Aghazadeh Y, Ahmad S, Kress B . Peripheral markers of Alzheimer's disease: surveillance of white blood cells. Synapse. 2013; 67(8):541-3. DOI: 10.1002/syn.21651. View

12.

Koc E, Uzar E, Cirak Y, Demir Y, Ilhan A . The increase of mean platelet volume in patients with Alzheimer disease. Turk J Med Sci. 2015; 44(6):1060-6. DOI: 10.3906/sag-1212-5. View

13.

Peers C, Dallas M, Boycott H, Scragg J, Pearson H, Boyle J . Hypoxia and neurodegeneration. Ann N Y Acad Sci. 2009; 1177:169-77. DOI: 10.1111/j.1749-6632.2009.05026.x. View

14.

OBryant S, Lacritz L, Hall J, Waring S, Chan W, Khodr Z . Validation of the new interpretive guidelines for the clinical dementia rating scale sum of boxes score in the national Alzheimer's coordinating center database. Arch Neurol. 2010; 67(6):746-9. PMC: 2888493. DOI: 10.1001/archneurol.2010.115. View

15.

Babiloni C, Percio C, Lizio R, Infarinato F, Blin O, Bartres-Faz D . A review of the effects of hypoxia, sleep deprivation and transcranial magnetic stimulation on EEG activity in humans: challenges for drug discovery for Alzheimer's disease. Curr Alzheimer Res. 2014; 11(5):501-18. DOI: 10.2174/1567205011666140317095623. View

16.

Bonotis K, Krikki E, Holeva V, Aggouridaki C, Costa V, Baloyannis S . Systemic immune aberrations in Alzheimer's disease patients. J Neuroimmunol. 2007; 193(1-2):183-7. DOI: 10.1016/j.jneuroim.2007.10.020. View

17.

Gendelman H, Mosley R . A Perspective on Roles Played by Innate and Adaptive Immunity in the Pathobiology of Neurodegenerative Disorders. J Neuroimmune Pharmacol. 2015; 10(4):645-50. PMC: 4662620. DOI: 10.1007/s11481-015-9639-4. View

18.

Schroeder J . Basophils beyond effector cells of allergic inflammation. Adv Immunol. 2009; 101:123-61. DOI: 10.1016/S0065-2776(08)01004-3. View

19.

Liu Y, Guo D, Tian L, Shang D, Zhao W, Li B . Peripheral T cells derived from Alzheimer's disease patients overexpress CXCR2 contributing to its transendothelial migration, which is microglial TNF-alpha-dependent. Neurobiol Aging. 2008; 31(2):175-88. DOI: 10.1016/j.neurobiolaging.2008.03.024. View

20.

Zhou D, Wang J, Li J, Deng J, Gao C, Chen M . Study on frequency and predictors of dementia after ischemic stroke: the Chongqing stroke study. J Neurol. 2004; 251(4):421-7. DOI: 10.1007/s00415-004-0337-z. View