Epithelial Patterning, Morphogenesis, and Evolution: Drosophila Eggshell As a Model

Overview

Journal Dev Cell

Publisher Cell Press

Specialties Cell Biology
Reproductive Medicine

Date 2017 May 24

PMID 28535370

Citations 26

Authors

Miriam Osterfield

Celeste A Berg

Stanislav Y Shvartsman

Affiliations

Soon will be listed here.

Abstract

Understanding the mechanisms driving tissue and organ formation requires knowledge across scales. How do signaling pathways specify distinct tissue types? How does the patterning system control morphogenesis? How do these processes evolve? The Drosophila egg chamber, where EGF and BMP signaling intersect to specify unique cell types that construct epithelial tubes for specialized eggshell structures, has provided a tractable system to ask these questions. Work there has elucidated connections between scales of development, including across evolutionary scales, and fostered the development of quantitative modeling tools. These tools and general principles can be applied to the understanding of other developmental processes across organisms.

Citing Articles

Multi-modal comparison of molecular programs driving nurse cell death and clearance in Drosophila melanogaster oogenesis.

Bandyadka S, Lebo D, Mondragon A, Serizier S, Kwan J, Peterson J PLoS Genet. 2025; 21(1):e1011220.

PMID: 39752622 PMC: 11734916. DOI: 10.1371/journal.pgen.1011220.

The Enigmas of Tissue Closure: Inspiration from .

Huang X, Su Z, Xie X Curr Issues Mol Biol. 2024; 46(8):8710-8725.

PMID: 39194731 PMC: 11352826. DOI: 10.3390/cimb46080514.

Basal actomyosin pulses expand epithelium coordinating cell flattening and tissue elongation.

Li S, Liu Z, Li H, Zhou S, Liu J, Sun N Nat Commun. 2024; 15(1):3000.

PMID: 38589403 PMC: 11001887. DOI: 10.1038/s41467-024-47236-1.

Revisiting bicoid function: complete inactivation reveals an additional fundamental role in Drosophila egg geometry specification.

Baumgartner S Hereditas. 2024; 161(1):1.

PMID: 38167241 PMC: 10759373. DOI: 10.1186/s41065-023-00305-9.

Finishing the egg.

Berg C, Sieber M, Sun J Genetics. 2023; 226(1).

PMID: 38000906 PMC: 10763546. DOI: 10.1093/genetics/iyad183.

References

Lachance J, Fregoso Lomas M, Eleiche A, Bouchard Kerr P, Nilson L . Graded Egfr activity patterns the Drosophila eggshell independently of autocrine feedback. Development. 2009; 136(17):2893-902. DOI: 10.1242/dev.036103. View

Twombly V, Blackman R, Jin H, Graff J, PADGETT R, Gelbart W . The TGF-beta signaling pathway is essential for Drosophila oogenesis. Development. 1996; 122(5):1555-65. DOI: 10.1242/dev.122.5.1555. View

Colas J, Schoenwolf G . Towards a cellular and molecular understanding of neurulation. Dev Dyn. 2001; 221(2):117-45. DOI: 10.1002/dvdy.1144. View

Lembong J, Yakoby N, Shvartsman S . Spatial regulation of BMP signaling by patterned receptor expression. Tissue Eng Part A. 2008; 14(9):1469-77. DOI: 10.1089/ten.tea.2008.0098. View

Shravage B, Altmann G, Technau M, Roth S . The role of Dpp and its inhibitors during eggshell patterning in Drosophila. Development. 2007; 134(12):2261-71. DOI: 10.1242/dev.02856. View

Peters N, Thayer N, Kerr S, Tompa M, Berg C . Following the 'tracks': Tramtrack69 regulates epithelial tube expansion in the Drosophila ovary through Paxillin, Dynamin, and the homeobox protein Mirror. Dev Biol. 2013; 378(2):154-69. PMC: 4141043. DOI: 10.1016/j.ydbio.2013.03.017. View

Boyle M, Berg C . Control in time and space: Tramtrack69 cooperates with Notch and Ecdysone to repress ectopic fate and shape changes during Drosophila egg chamber maturation. Development. 2009; 136(24):4187-97. PMC: 2781054. DOI: 10.1242/dev.042770. View

Manning L, Starz-Gaiano M . Culturing Drosophila Egg Chambers and Investigating Developmental Processes Through Live Imaging. Methods Mol Biol. 2015; 1328:73-88. DOI: 10.1007/978-1-4939-2851-4_5. View

Condic M, Fristrom D, Fristrom J . Apical cell shape changes during Drosophila imaginal leg disc elongation: a novel morphogenetic mechanism. Development. 1991; 111(1):23-33. DOI: 10.1242/dev.111.1.23. View

10.

Campas O . A toolbox to explore the mechanics of living embryonic tissues. Semin Cell Dev Biol. 2016; 55:119-30. PMC: 4903887. DOI: 10.1016/j.semcdb.2016.03.011. View

11.

Cetera M, Juan G, Oakes P, Lewellyn L, Fairchild M, Tanentzapf G . Epithelial rotation promotes the global alignment of contractile actin bundles during Drosophila egg chamber elongation. Nat Commun. 2014; 5:5511. PMC: 4241503. DOI: 10.1038/ncomms6511. View

12.

Peters N, Berg C . Dynamin-mediated endocytosis is required for tube closure, cell intercalation, and biased apical expansion during epithelial tubulogenesis in the Drosophila ovary. Dev Biol. 2015; 409(1):39-54. PMC: 4697861. DOI: 10.1016/j.ydbio.2015.10.034. View

13.

Hudson A, Cooley L . Methods for studying oogenesis. Methods. 2014; 68(1):207-17. PMC: 4048766. DOI: 10.1016/j.ymeth.2014.01.005. View

14.

Chen Y, Schupbach T . The role of brinker in eggshell patterning. Mech Dev. 2006; 123(5):395-406. DOI: 10.1016/j.mod.2006.03.007. View

15.

Niepielko M, Yakoby N . Evolutionary changes in TGFα distribution underlie morphological diversity in eggshells from Drosophila species. Development. 2014; 141(24):4710-5. PMC: 4299280. DOI: 10.1242/dev.111898. View

16.

Hashimoto H, Robin F, Sherrard K, Munro E . Sequential contraction and exchange of apical junctions drives zippering and neural tube closure in a simple chordate. Dev Cell. 2015; 32(2):241-55. DOI: 10.1016/j.devcel.2014.12.017. View

17.

Pare A, Vichas A, Fincher C, Mirman Z, Farrell D, Mainieri A . A positional Toll receptor code directs convergent extension in Drosophila. Nature. 2014; 515(7528):523-7. PMC: 4943584. DOI: 10.1038/nature13953. View

18.

Peri F, Roth S . Combined activities of Gurken and decapentaplegic specify dorsal chorion structures of the Drosophila egg. Development. 2000; 127(4):841-50. DOI: 10.1242/dev.127.4.841. View

19.

Martin A, Gelbart M, Fernandez-Gonzalez R, Kaschube M, Wieschaus E . Integration of contractile forces during tissue invagination. J Cell Biol. 2010; 188(5):735-49. PMC: 2835944. DOI: 10.1083/jcb.200910099. View

20.

Laplante C, Nilson L . Asymmetric distribution of Echinoid defines the epidermal leading edge during Drosophila dorsal closure. J Cell Biol. 2011; 192(2):335-48. PMC: 3172166. DOI: 10.1083/jcb.201009022. View