Control of Gene Expression Through the Nonsense-mediated RNA Decay Pathway

Overview

Journal Cell Biosci

Publisher Biomed Central

Specialty Biology

Date 2017 May 24

PMID 28533900

Citations 100

Authors

Andrew Nickless

Julie M Bailis

Zhongsheng You

Affiliations

Soon will be listed here.

Abstract

Nonsense-mediated RNA decay (NMD) was originally discovered as a cellular surveillance pathway that safeguards the quality of mRNA transcripts in eukaryotic cells. In its canonical function, NMD prevents translation of mutant mRNAs harboring premature termination codons (PTCs) by targeting them for degradation. However, recent studies have shown that NMD has a much broader role in gene expression by regulating the stability of many normal transcripts. In this review, we discuss the function of NMD in normal physiological processes, its dynamic regulation by developmental and environmental cues, and its association with human disease.

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