Coadministration of Liposomal Amphotericin B and Contrast Medium Does Not Increase Risk of Kidney Injury

Overview

Journal Antimicrob Agents Chemother

Publisher American Society for Microbiology

Specialty Pharmacology

Date 2017 May 24

PMID 28533242

Citations 1

Authors

John C OHoro

Douglas R Osmon

Omar M Abu Saleh

Jasmine R Marcelin

Kamel A Gharaibeh

Abdurrahman M Hamadah

Amelia K Barwise

Bryce M Kayhart

Jennifer S McDonald

Robert J McDonald

Nelson Leung

Affiliations

Soon will be listed here.

Abstract

Intravenous radiographic contrast medium and amphotericin B are commonly required in the care of patients with fungal infections. Both interventions have proposed nephrotoxicity through similar mechanisms. We systematically examined patients who received coadministration of liposomal amphotericin B (AmBisome; GE Healthcare) and intravenous contrast medium within a 24-h period and compared the results for those patients with the results for patients who underwent non-contrast medium studies. We found 114 cases and 85 controls during our study period. Overall, no increased risk of renal injury was seen with coadministration of these 2 agents. Adjustment for age, baseline kidney function, and other clinical factors through propensity score adjustment did not change this result. Our observations suggest that, when clinically indicated, coadministration of contrast medium and liposomal amphotericin B does not present excess risk compared with that from the administration of liposomal amphotericin B alone.

Citing Articles

Retrospective Cohort Analysis of Liposomal Amphotericin B Nephrotoxicity in Patients with Hematological Malignancies.

Stanzani M, Vianelli N, Cavo M, Maritati A, Morotti M, Lewis R Antimicrob Agents Chemother. 2017; 61(9).

PMID: 28607011 PMC: 5571305. DOI: 10.1128/AAC.02651-16.

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