Synthesis and Excellent Duplex Stability of Oligonucleotides Containing 2'-Amino-LNA Functionalized with Galactose Units

Overview

Journal Molecules

Publisher MDPI

Specialty Biology

Date 2017 May 23

PMID 28531137

Citations 3

Authors

Rajesh Kumar

Annika Ries

Jesper Wengel

Affiliations

Soon will be listed here.

Abstract

A convenient method for the preparation of oligonucleotides containing internally-attached galactose and triantennary galactose units has been developed based on click chemistry between 2'--alkyne 2'-amino-LNA nucleosides and azido-functionalized galactosyl building blocks. The synthesized oligonucleotides show excellent binding affinity and selectivity towards complementary DNA/RNA strands with an increase in the melting temperature of up to +23.5 °C for triply-modified variants.

Citing Articles

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Horie N, Yamaguchi T, Kumagai S, Obika S Beilstein J Org Chem. 2021; 17:622-629.

PMID: 33747234 PMC: 7940814. DOI: 10.3762/bjoc.17.54.

Synthesis of Oligonucleotides Containing 2'--alkylaminocarbonyl-2'-amino-LNA (2'-urea-LNA) Moieties Using Post-Synthetic Modification Strategy.

Yamashita S, Nishida K, Osawa T, Nakanishi A, Ito Y, Hari Y Molecules. 2020; 25(2).

PMID: 31952133 PMC: 7024358. DOI: 10.3390/molecules25020346.

Special Issue "Synthesis and Applications of Oligonucleotide Conjugates".

Lonnberg H Molecules. 2017; 22(10).

PMID: 29027972 PMC: 6151427. DOI: 10.3390/molecules22101700.

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