[Modification of Nucleic Acids Using [3+2] Dipolar Cycloaddition of Azides and Alkynes]

Overview

Journal Bioorg Khim

Specialties Biochemistry
Molecular Biology

Date 2010 Sep 9

PMID 20823915

Citations 4

Authors

A V Ustinov

I A Stepanova

V V Dubniakova

T S Zatsepin

E V Nozhevnikova

V A Korshun

Affiliations

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Abstract

The use of the reaction of azide and alkyne cycloaddition for the synthesis of nucleic acid conjugates and DNA oligomer analogues is considered. The data on chemical and enzymatic techniques of azides and alkynes introduction into DNA are summarized.

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