Interfering Satellite RNAs of

Overview

Journal Front Microbiol

Specialty Microbiology

Date 2017 May 20

PMID 28522996

Citations 3

Authors

Kuan-Yu Lin

Na-Sheng Lin

Affiliations

Soon will be listed here.

Abstract

Satellite RNAs (satRNAs) are sub-viral agents that may interact with their cognate helper virus (HV) and host plant synergistically and/or antagonistically. SatRNAs totally depend on the HV for replication, so satRNAs and HV usually evolve similar secondary or tertiary RNA structures that are recognized by a replication complex, although satRNAs and HV do not share an appreciable sequence homology. The satRNAs of (satBaMV), the only satRNAs of the genus , have become one of the models of how satRNAs can modulate HV replication and virus-induced symptoms. In this review, we summarize the molecular mechanisms underlying the interaction of interfering satBaMV and BaMV. Like other satRNAs, satBaMV mimics the secondary structures of 5'- and 3'-untranslated regions (UTRs) of BaMV as a molecular pretender. However, a conserved apical hairpin stem loop (AHSL) in the 5'-UTR of satBaMV was found as the key determinant for downregulating BaMV replication. In particular, two unique nucleotides (C and C) in the AHSL of satBaMVs determine the satBaMV interference ability by competing for the replication machinery. Thus, transgenic plants expressing interfering satBaMV could confer resistance to BaMV, and interfering satBaMV could be used as biological-control agent. Unlike two major anti-viral mechanisms, RNA silencing and salicylic acid-mediated immunity, our findings in plants by competition assay and RNA deep sequencing suggested replication competition is involved in this transgenic satBaMV-mediated BaMV interference. We propose how a single nucleotide of satBaMV can make a great change in BaMV pathogenicity and the underlying mechanism.

Citing Articles

The non-template functions of helper virus RNAs create optimal replication conditions to enhance the proliferation of satellite RNAs.

Qiao Z, Wang J, Huang K, Hu H, Gu Z, Liao Q PLoS Pathog. 2024; 20(4):e1012174.

PMID: 38630801 PMC: 11057728. DOI: 10.1371/journal.ppat.1012174.

Identification of Host Factors Interacting with a γ-Shaped RNA Element from a Plant Virus-Associated Satellite RNA.

Li M, Zhang X, Huang K, Du Z Viruses. 2023; 15(10).

PMID: 37896816 PMC: 10611174. DOI: 10.3390/v15102039.

Trade-off between local replication and long-distance dissemination during experimental evolution of a satellite RNA.

Lee S, Liou M, Hsu Y, Wang I, Lin N Front Microbiol. 2023; 14:1139447.

PMID: 37601360 PMC: 10436602. DOI: 10.3389/fmicb.2023.1139447.

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