S100A11 Regulates Renal Carcinoma Cell Proliferation, Invasion, and Migration Via the EGFR/Akt Signaling Pathway and E-cadherin

Overview

Journal Tumour Biol

Publisher Sage Publications

Specialty Oncology

Date 2017 May 18

PMID 28513300

Citations 11

Authors

Lin Liu

Long Miao

Yang Liu

Aihua Qi

Ping Xie

Jiacun Chen

Haitao Zhu

Affiliations

Soon will be listed here.

Abstract

S100A11 is a S100 protein family member that contributes to cancer progression. Upregulated in human renal cancer tissues, S100A11 may be a prognostic marker for clear cell renal cell carcinoma, but how it functions in cancer is uncertain. Thus, we studied S100A11 and noted knockdown of S100A11 using short hairpin RNA, which inhibited proliferation, invasion, and migration of renal carcinoma cells as well as increased expression of E-cadherin and decreased expression of epidermal growth factor receptor/Akt in renal carcinoma cells. Therefore, S100A11 may be a key molecular target for treating renal carcinoma.

Citing Articles

An in vitro approach to understand contribution of kidney cells to human urinary extracellular vesicles.

Barreiro K, Lay A, Leparc G, Tran V, Rosler M, Dayalan L J Extracell Vesicles. 2023; 12(2):e12304.

PMID: 36785873 PMC: 9925963. DOI: 10.1002/jev2.12304.

Novel plasma protein biomarkers from critically ill sepsis patients.

Van Nynatten L, Slessarev M, Martin C, Leligdowicz A, Miller M, Patel M Clin Proteomics. 2022; 19(1):50.

PMID: 36572854 PMC: 9792322. DOI: 10.1186/s12014-022-09389-3.

KIF18A promotes head and neck squamous cell carcinoma invasion and migration via activation of Akt signaling pathway.

Liu G, Cai G, He X, Huang D, Zhu G, Chen C Transl Cancer Res. 2022; 8(6):2252-2263.

PMID: 35116978 PMC: 8798418. DOI: 10.21037/tcr.2019.09.38.

RHBDD1 promotes proliferation, migration, invasion and EMT in renal cell carcinoma via the EGFR/AKT signaling pathway.

Li M, Cai L, Wang X, Yu Y, Jian W, Bao G Mol Med Rep. 2021; 24(6).

PMID: 34581421 PMC: 8503741. DOI: 10.3892/mmr.2021.12466.

VHL-HIF-2α axis-induced SMYD3 upregulation drives renal cell carcinoma progression via direct trans-activation of EGFR.

Liu C, Liu L, Wang K, Li X, Ge L, Ma R Oncogene. 2020; 39(21):4286-4298.

PMID: 32291411 DOI: 10.1038/s41388-020-1291-7.