Ginkgolic Acid Inhibits the Growth of Renal Cell Carcinoma Cells Via Inactivation of the EGFR Signaling Pathway

Overview

Journal Exp Ther Med

Specialty Pathology

Date 2020 Apr 8

PMID 32256780

Citations 5

Authors

Chao Zhu

Na Na

Haibo Sheng

Bing Feng

Hao Wang

Ping Zhu

Wei Zhang

Meina Zhang

Zhen Deng

Affiliations

Soon will be listed here.

Abstract

Renal cell carcinoma (RCC) is one of the most common urological malignancies occurring in adult human kidneys worldwide. Recent research on antitumor drugs has focused on plant extracts, a class of compounds that play critical roles in cancer treatment. The present study aimed to investigate the potential antitumor effect of ginkgolic acid (GA) in RCC. Transwell invasion assay, cell counting kit-8 assay and flow cytometry were used to measure cell migration, cell viability and apoptosis, respectively. A network pharmacology approach was applied to identify pathway information, combining molecular docking techniques to screen for key target information. In the present study, GA inhibited the viability and proliferation of RCC cells (786-O and A498), both and , via G arrest. GA also reduced RCC cell invasion and migration. In addition, the epidermal growth factor receptor (EGFR) was identified as a critical target protein of GA, which significantly inactivated EGFR signaling in RCC (P<0.05). Collectively, the present study provided evidence that GA exerts its anticancer function by directly targeting the EGFR signaling pathway, revealing the potential of GA therapy for RCC.

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