Knockdown of LncRNA-PANDAR Suppresses the Proliferation, Cell Cycle and Promotes Apoptosis in Thyroid Cancer Cells
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Long non-coding RNAs (lncRNAs) have been found to show important regulatory roles in various human cancers. Lnc-RNA PANDAR is a novel identified lncRNA that was previously reported to show abnormal expression pattern in various cancers. However, little is known of its expression and biological function in thyroid cancer. Here, we used the quantitative real-time PCR (qRT-PCR) to determine the expression of PANDAR in 64 thyroid cancer tissues. We found that expression of PANDAR was up-regulated in thyroid cancer tissues compared with adjacent non-tumor tissues. Functional assays demonstrated that knockdown of PANDAR could inhibit proliferation, cell cycle progression, induces the apoptosis, inhibit invasion of thyroid cancer cells. Thus, our study provides evidence that PANDAR may function as a potential target for treatment for patients with thyroid cancer.
Guo J, Xiao D, Lin Z, Sui C Histol Histopathol. 2022; 38(2):199-208.
PMID: 36073766 DOI: 10.14670/HH-18-511.
Differential gene expression profile of multinodular goiter.
Figueiredo W, Lopes E, Jezini D, Marcal L, Assuncao E, Ribeiro Rodrigues P PLoS One. 2022; 17(5):e0268354.
PMID: 35594253 PMC: 9122239. DOI: 10.1371/journal.pone.0268354.
LncRNA-PANDAR regulates the progression of thyroid carcinoma by targeting miR-637/KLK4.
Qing Y, Li Q, Zhao L, Shi P, Shan J, Zhang W J Cancer. 2021; 12(19):5879-5887.
PMID: 34476001 PMC: 8408101. DOI: 10.7150/jca.55181.
Liang M, Wang H, Liu C, Lei T, Min J Cancer Cell Int. 2021; 21(1):440.
PMID: 34419049 PMC: 8379738. DOI: 10.1186/s12935-021-02061-0.
The Role of Non-Coding RNAs in Controlling Cell Cycle Related Proteins in Cancer Cells.
Ghafouri-Fard S, Shoorei H, Tondro Anamag F, Taheri M Front Oncol. 2020; 10:608975.
PMID: 33330110 PMC: 7734207. DOI: 10.3389/fonc.2020.608975.