DDX11-AS1 As Potential Therapy Targets for Human Hepatocellular Carcinoma

Overview

Journal Oncotarget

Specialty Oncology

Date 2017 May 13

PMID 28496001

Citations 11

Authors

Min Shi

Xiao-Yu Zhang

Heguo Yu

Shi-Hao Xiang

Ling Xu

Jue Wei

Qiong Wu

Rongrong Jia

Yu-Gang Wang

Xiao-Jie Lu

Affiliations

Soon will be listed here.

Abstract

Hepatocellular Carcinoma (HCC) is one of the most fatal cancers, whose incidence and death rates are still rising. Here, we report the identification of long non-coding RNAs (IncRNAs) that associated with HCC progression and metabolism based on the systematically analysis of large scale RNA-seq data from HCC patients. We identified seven lncRNAs with high confidence which were highly related with prognostic of HCC. Of note, three of them had quite different expression patterns between the control samples and the patients, and their critical roles in cancer progression were validated. We proposed that DDX11-AS1 play important role during HCC oncogenesis and may serve as potential therapy target for HCC.

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