Macrophage Function in Tissue Repair and Remodeling Requires IL-4 or IL-13 with Apoptotic Cells

Overview

Journal Science

Specialty Science

Date 2017 May 13

PMID 28495875

Citations 286

Authors

Lidia Bosurgi

Y Grace Cao

Mar Cabeza-Cabrerizo

Andrea Tucci

Lindsey D Hughes

Yong Kong

Jason S Weinstein

Paula Licona-Limon

Edward T Schmid

Facundo Pelorosso

Nicola Gagliani

Joseph E Craft

Richard A Flavell

Sourav Ghosh

Carla V Rothlin

Affiliations

Soon will be listed here.

Abstract

Tissue repair is a subset of a broad repertoire of interleukin-4 (IL-4)- and IL-13-dependent host responses during helminth infection. Here we show that IL-4 or IL-13 alone was not sufficient, but IL-4 or IL-13 together with apoptotic cells induced the tissue repair program in macrophages. Genetic ablation of sensors of apoptotic cells impaired the proliferation of tissue-resident macrophages and the induction of anti-inflammatory and tissue repair genes in the lungs after helminth infection or in the gut after induction of colitis. By contrast, the recognition of apoptotic cells was dispensable for cytokine-dependent induction of pattern recognition receptor, cell adhesion, or chemotaxis genes in macrophages. Detection of apoptotic cells can therefore spatially compartmentalize or prevent premature or ectopic activity of pleiotropic, soluble cytokines such as IL-4 or IL-13.

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