An Essential Role for TH2-type Responses in Limiting Acute Tissue Damage During Experimental Helminth Infection

Overview

Journal Nat Med

Specialties General Medicine
Molecular Biology

Date 2012 Jan 17

PMID 22245779

Citations 263

Authors

Fei Chen

Zhugong Liu

Wenhui Wu

Cristina Rozo

Scott Bowdridge

Ariel Millman

Nico van Rooijen

Joseph F Urban Jr

Thomas A Wynn

William C Gause

Affiliations

Soon will be listed here.

Abstract

Helminths induce potent T helper 2 (TH2)-type immune responses that can mediate worm expulsion, but the role of this response in controlling the acute tissue damage caused by migrating multicellular parasites through vital tissues remains uncertain. We used a helminth infection model in which parasitic nematode larvae migrate transiently through the lung, resulting in hemorrhage and inflammation. We found that IL-17 initially contributed to inflammation and lung damage, whereas subsequent IL-4 receptor (IL-4R) signaling reduced elevations in IL-17 mRNA levels, enhanced the expression of insulin-like growth factor 1 (IGF-1) and IL-10 and stimulated the development of M2 macrophages, all of which contributed to the rapid resolution of tissue damage. These studies indicate an essential role for TH2-type immune responses in mediating acute wound healing during helminth infection.

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