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Platelets As Crucial Partners for Tumor Metastasis: from Mechanistic Aspects to Pharmacological Targeting

Overview
Publisher Springer
Specialty Biology
Date 2017 May 11
PMID 28488110
Citations 36
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Abstract

Platelets are anucleated cells that circulate in the blood as sentinels of tissue integrity. In fact, they are rich in a plethora of proteins and other factors stored in different granules which they selectively release upon stimulation. Moreover, platelets synthesize a vast number of lipids and release various types of vesicles, including exosomes which are rich in genetic material. Platelets possess a central function to interact with other cell types, including inflammatory cells and cancer cells. Recent findings have enlightened the capacity of platelets to induce changes in the phenotype of cancer cells which acquire invasiveness thus enhancing their metastatic potential. Thus, it has been hypothesized that targeting the platelet may represent a novel strategy to prevent the development and progression of cancer. This is supported by the efficacy of the antiplatelet agent low-dose aspirin. Studies are ongoing to verify whether other antiplatelet agents share the anticancer effectiveness of aspirin.

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References
1.
Steeg P . Targeting metastasis. Nat Rev Cancer. 2016; 16(4):201-18. PMC: 7055530. DOI: 10.1038/nrc.2016.25. View

2.
Dovizio M, Alberti S, Guillem-Llobat P, Patrignani P . Role of platelets in inflammation and cancer: novel therapeutic strategies. Basic Clin Pharmacol Toxicol. 2013; 114(1):118-27. DOI: 10.1111/bcpt.12156. View

3.
Smith W, Dewitt D, Garavito R . Cyclooxygenases: structural, cellular, and molecular biology. Annu Rev Biochem. 2000; 69:145-82. DOI: 10.1146/annurev.biochem.69.1.145. View

4.
Boulaftali Y, Hess P, Kahn M, Bergmeier W . Platelet immunoreceptor tyrosine-based activation motif (ITAM) signaling and vascular integrity. Circ Res. 2014; 114(7):1174-84. PMC: 4000726. DOI: 10.1161/CIRCRESAHA.114.301611. View

5.
Song W, Stubbe J, Ricciotti E, Alamuddin N, Ibrahim S, Crichton I . Niacin and biosynthesis of PGD₂by platelet COX-1 in mice and humans. J Clin Invest. 2012; 122(4):1459-68. PMC: 3314457. DOI: 10.1172/JCI59262. View