Activation of Brain Somatostatin Signaling Suppresses CRF Receptor-Mediated Stress Response

Overview

Journal Front Neurosci

Date 2017 May 11

PMID 28487631

Citations 22

Authors

Andreas Stengel

Yvette F Tache

Affiliations

Soon will be listed here.

Abstract

Corticotropin-releasing factor (CRF) is the hallmark brain peptide triggering the response to stress and mediates-in addition to the stimulation of the hypothalamus-pituitary-adrenal (HPA) axis-other hormonal, behavioral, autonomic and visceral components. Earlier reports indicate that somatostatin-28 injected intracerebroventricularly counteracts the acute stress-induced ACTH and catecholamine release. Mounting evidence now supports that activation of brain somatostatin signaling exerts a broader anti-stress effect by blunting the endocrine, autonomic, behavioral (with a focus on food intake) and visceral gastrointestinal motor responses through the involvement of distinct somatostatin receptor subtypes.

Citing Articles

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Somatostatin: Linking Cognition and Alzheimer Disease to Therapeutic Targeting.

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Somatostatin peptide signaling dampens cortical circuits and promotes exploratory behavior.

Brockway D, Griffith K, Aloimonos C, Clarity T, Moyer J, Smith G Cell Rep. 2023; 42(8):112976.

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Somatostatin signaling modulates binge drinking behavior via the central nucleus of the amygdala.

Robinson S, Thiele T Neuropharmacology. 2023; 237:109622.

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References

Spary E, Maqbool A, Batten T . Expression and localisation of somatostatin receptor subtypes sst1-sst5 in areas of the rat medulla oblongata involved in autonomic regulation. J Chem Neuroanat. 2007; 35(1):49-66. DOI: 10.1016/j.jchemneu.2007.06.002. View

Bou Farah L, Bowman B, Bokiniec P, Karim S, Le S, Goodchild A . Somatostatin in the rat rostral ventrolateral medulla: Origins and mechanism of action. J Comp Neurol. 2015; 524(2):323-42. DOI: 10.1002/cne.23846. View

Kuhne C, Puk O, Graw J, de Angelis M, Schutz G, Wurst W . Visualizing corticotropin-releasing hormone receptor type 1 expression and neuronal connectivities in the mouse using a novel multifunctional allele. J Comp Neurol. 2012; 520(14):3150-80. DOI: 10.1002/cne.23082. View

Stengel A, Karasawa H, Tache Y . The role of brain somatostatin receptor 2 in the regulation of feeding and drinking behavior. Horm Behav. 2015; 73:15-22. PMC: 4546908. DOI: 10.1016/j.yhbeh.2015.05.009. View

Monnikes H, Raybould H, Schmidt B, Tache Y . CRF in the paraventricular nucleus of the hypothalamus stimulates colonic motor activity in fasted rats. Peptides. 1993; 14(4):743-7. DOI: 10.1016/0196-9781(93)90107-r. View

PERRIN M, Vale W . Corticotropin releasing factor receptors and their ligand family. Ann N Y Acad Sci. 2000; 885:312-28. DOI: 10.1111/j.1749-6632.1999.tb08687.x. View

Stengel A, Tache Y . Brain peptides and the modulation of postoperative gastric ileus. Curr Opin Pharmacol. 2014; 19:31-7. PMC: 4254047. DOI: 10.1016/j.coph.2014.06.006. View

Fehlmann D, Langenegger D, Schuepbach E, Siehler S, Feuerbach D, Hoyer D . Distribution and characterisation of somatostatin receptor mRNA and binding sites in the brain and periphery. J Physiol Paris. 2000; 94(3-4):265-81. DOI: 10.1016/s0928-4257(00)00208-4. View

Gravanis A, Margioris A . The corticotropin-releasing factor (CRF) family of neuropeptides in inflammation: potential therapeutic applications. Curr Med Chem. 2005; 12(13):1503-12. DOI: 10.2174/0929867054039008. View

10.

Hillhouse E, Grammatopoulos D . The molecular mechanisms underlying the regulation of the biological activity of corticotropin-releasing hormone receptors: implications for physiology and pathophysiology. Endocr Rev. 2006; 27(3):260-86. DOI: 10.1210/er.2005-0034. View

11.

Priego T, de Caceres I, Martin A, Villanua M, Lopez-Calderon A . Endotoxin administration increases hypothalamic somatostatin mRNA through nitric oxide release. Regul Pept. 2004; 124(1-3):113-8. DOI: 10.1016/j.regpep.2004.07.001. View

12.

FINLEY J, Maderdrut J, Roger L, Petrusz P . The immunocytochemical localization of somatostatin-containing neurons in the rat central nervous system. Neuroscience. 1981; 6(11):2173-92. DOI: 10.1016/0306-4522(81)90006-3. View

13.

HANNON J, Petrucci C, Fehlmann D, Viollet C, Epelbaum J, Hoyer D . Somatostatin sst2 receptor knock-out mice: localisation of sst1-5 receptor mRNA and binding in mouse brain by semi-quantitative RT-PCR, in situ hybridisation histochemistry and receptor autoradiography. Neuropharmacology. 2002; 42(3):396-413. DOI: 10.1016/s0028-3908(01)00186-1. View

14.

Reyes T, Lewis K, PERRIN M, Kunitake K, Vaughan J, Arias C . Urocortin II: a member of the corticotropin-releasing factor (CRF) neuropeptide family that is selectively bound by type 2 CRF receptors. Proc Natl Acad Sci U S A. 2001; 98(5):2843-8. PMC: 30227. DOI: 10.1073/pnas.051626398. View

15.

Pradayrol L, Jornvall H, Mutt V, Ribet A . N-terminally extended somatostatin: the primary structure of somatostatin-28. FEBS Lett. 1980; 109(1):55-8. DOI: 10.1016/0014-5793(80)81310-x. View

16.

Reichmann F, Holzer P . Neuropeptide Y: A stressful review. Neuropeptides. 2015; 55:99-109. PMC: 4830398. DOI: 10.1016/j.npep.2015.09.008. View

17.

Butler R, White L, Frederick-Duus D, Kaigler K, Fadel J, Wilson M . Comparison of the activation of somatostatin- and neuropeptide Y-containing neuronal populations of the rat amygdala following two different anxiogenic stressors. Exp Neurol. 2012; 238(1):52-63. PMC: 3456992. DOI: 10.1016/j.expneurol.2012.08.002. View

18.

Polkowska J, Wankowska M . Effects of maternal deprivation on the somatotrophic axis and neuropeptide Y in the hypothalamus and pituitary in female lambs. The histomorphometric study. Folia Histochem Cytobiol. 2010; 48(2):299-305. DOI: 10.2478/v10042-010-0024-0. View

19.

Mitsugi N, Arita J, Kimura F . Effects of intracerebroventricular administration of growth hormone-releasing factor and corticotropin-releasing factor on somatostatin secretion into rat hypophysial portal blood. Neuroendocrinology. 1990; 51(1):93-6. DOI: 10.1159/000125322. View

20.

Burke P, Li Q, Costin M, McMullan S, Pilowsky P, Goodchild A . Somatostatin 2A receptor-expressing presympathetic neurons in the rostral ventrolateral medulla maintain blood pressure. Hypertension. 2008; 52(6):1127-33. DOI: 10.1161/HYPERTENSIONAHA.108.118224. View