Brain Peptides and the Modulation of Postoperative Gastric Ileus

Overview

Journal Curr Opin Pharmacol

Specialty Pharmacology

Date 2014 Jul 8

PMID 24999843

Citations 5

Authors

Andreas Stengel

Yvette Tache

Affiliations

Soon will be listed here.

Abstract

Postoperative ileus (POI) develops after abdominal surgery irrespective of the site of surgery. When prolonged, POI can lead to longer hospitalization times and higher healthcare costs. Moreover, it is associated with complaints for the patient. In order to develop new strategies to treat this condition, a deeper understanding of the pathophysiology of the POI is necessary. This review will focus on brain peptides (ghrelin, nesfatin-1, somatostatin, corticotropin-releasing factor, thyrotropin-releasing hormone and calcitonin gene-related peptide) involved in the mediation of POI and the possible modulation of these pathways to shorten the time of POI. Lastly, the role of vagal signaling or chewing gum as potential treatment strategies of alleviating symptoms of POI is discussed.

Citing Articles

Postoperative delayed gastric emptying: may gut microbiota play a role?.

Wang Z, Liu C, Hu K, Zuo M, Tian Z, Wei Y Front Cell Infect Microbiol. 2024; 14:1449530.

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Activation of Brain Somatostatin Signaling Suppresses CRF Receptor-Mediated Stress Response.

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Hesperidin alleviates rat postoperative ileus through anti-inflammation and stimulation of Ca(2+)-dependent myosin phosphorylation.

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Patterns of Brain Activation and Meal Reduction Induced by Abdominal Surgery in Mice and Modulation by Rikkunshito.

Wang L, Mogami S, Yakabi S, Karasawa H, Yamada C, Yakabi K PLoS One. 2015; 10(9):e0139325.

PMID: 26421719 PMC: 4589401. DOI: 10.1371/journal.pone.0139325.

The role of brain somatostatin receptor 2 in the regulation of feeding and drinking behavior.

Stengel A, Karasawa H, Tache Y Horm Behav. 2015; 73:15-22.

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