Relationship Between Exclusive Breastfeeding and Lower Risk of Childhood Obesity: A Narrative Review of Published Evidence

Overview

Journal Clin Med Insights Pediatr

Publisher Sage Publications

Specialty Pediatrics

Date 2017 May 5

PMID 28469518

Citations 33

Authors

Samuel N Uwaezuoke

Chizoma I Eneh

Ikenna K Ndu

Affiliations

Soon will be listed here.

Abstract

Background: The pattern of infant feeding during the first 1000-day period-from conception to the second birthday-has a significant influence on the child's growth trajectory. The relationship between exclusive breastfeeding and lower risk of childhood obesity has elicited much scientific interest, given the fact that this form of malnutrition is becoming a global epidemic.

Aim: This narrative review aims to examine the evidence in the literature linking exclusive breastfeeding with reduction in obesity in children.

Literature Search: Using appropriate search terms, PubMed database was searched for relevant articles that met the review objective.

Results: Evidence for the protective effect of exclusive breastfeeding against childhood obesity have been provided by studies which explored 5 physiologic mechanisms and those that established the causality between breastfeeding and lower risk of obesity. The few studies that disputed this relationship highlighted the influence of confounding factors. A new insight on molecular mechanisms, however, points to a direct and indirect effect of human milk oligosaccharides on the prevention of overweight and obesity.

Conclusions: The preponderance of current evidence strongly suggests that exclusivity in breastfeeding can prevent the development of obesity in children.

Citing Articles

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Calcaterra V, Cena H, Sottotetti F, Rossi V, Loperfido F, Zuccotti G Children (Basel). 2023; 10(10).

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References

Heinig M, Nommsen L, Peerson J, Lonnerdal B, Dewey K . Energy and protein intakes of breast-fed and formula-fed infants during the first year of life and their association with growth velocity: the DARLING Study. Am J Clin Nutr. 1993; 58(2):152-61. DOI: 10.1093/ajcn/58.2.152. View

Koletzko B, von Kries R, Closa R, Escribano J, Scaglioni S, Giovannini M . Lower protein in infant formula is associated with lower weight up to age 2 y: a randomized clinical trial. Am J Clin Nutr. 2009; 89(6):1836-45. DOI: 10.3945/ajcn.2008.27091. View

Zheng J, Liu H, Li J, Chen Y, Wei C, Shen G . Exclusive breastfeeding is inversely associated with risk of childhood overweight in a large Chinese cohort. J Nutr. 2014; 144(9):1454-9. DOI: 10.3945/jn.114.193664. View

Verstraete S, Heyman M, Wojcicki J . Breastfeeding offers protection against obesity in children of recently immigrated Latina women. J Community Health. 2013; 39(3):480-6. PMC: 4618504. DOI: 10.1007/s10900-013-9781-y. View

Grube M, Von der Lippe E, Schlaud M, Brettschneider A . Does breastfeeding help to reduce the risk of childhood overweight and obesity? A propensity score analysis of data from the KiGGS study. PLoS One. 2015; 10(3):e0122534. PMC: 4374721. DOI: 10.1371/journal.pone.0122534. View

Barlow S . Expert committee recommendations regarding the prevention, assessment, and treatment of child and adolescent overweight and obesity: summary report. Pediatrics. 2007; 120 Suppl 4:S164-92. DOI: 10.1542/peds.2007-2329C. View

DiSantis K, Collins B, Fisher J, Davey A . Do infants fed directly from the breast have improved appetite regulation and slower growth during early childhood compared with infants fed from a bottle?. Int J Behav Nutr Phys Act. 2011; 8:89. PMC: 3170240. DOI: 10.1186/1479-5868-8-89. View

Woo J, Martin L . Does Breastfeeding Protect Against Childhood Obesity? Moving Beyond Observational Evidence. Curr Obes Rep. 2015; 4(2):207-16. DOI: 10.1007/s13679-015-0148-9. View

Kramer M . Do breast-feeding and delayed introduction of solid foods protect against subsequent obesity?. J Pediatr. 1981; 98(6):883-7. DOI: 10.1016/s0022-3476(81)80579-3. View

10.

Kramer M, Guo T, Platt R, Vanilovich I, Sevkovskaya Z, Dzikovich I . Feeding effects on growth during infancy. J Pediatr. 2004; 145(5):600-5. DOI: 10.1016/j.jpeds.2004.06.069. View

11.

Turnbaugh P, Ley R, Mahowald M, Magrini V, Mardis E, Gordon J . An obesity-associated gut microbiome with increased capacity for energy harvest. Nature. 2006; 444(7122):1027-31. DOI: 10.1038/nature05414. View

12.

Owen C, Martin R, Whincup P, Davey Smith G, Cook D . Does breastfeeding influence risk of type 2 diabetes in later life? A quantitative analysis of published evidence. Am J Clin Nutr. 2006; 84(5):1043-54. DOI: 10.1093/ajcn/84.5.1043. View

13.

Jing H, Xu H, Wan J, Yang Y, Ding H, Chen M . Effect of breastfeeding on childhood BMI and obesity: the China Family Panel Studies. Medicine (Baltimore). 2014; 93(10):e55. PMC: 4616333. DOI: 10.1097/MD.0000000000000055. View

14.

Kolcic I . Double burden of malnutrition: A silent driver of double burden of disease in low- and middle-income countries. J Glob Health. 2013; 2(2):020303. PMC: 3529312. DOI: 10.7189/jogh.02.020303. View

15.

Anderson J, Hayes D, Chock L . Characteristics of overweight and obesity at age two and the association with breastfeeding in Hawai'i Women, Infants, and Children (WIC) participants. Matern Child Health J. 2013; 18(10):2323-31. DOI: 10.1007/s10995-013-1392-9. View

16.

Ogden C, Carroll M, Kit B, Flegal K . Prevalence of childhood and adult obesity in the United States, 2011-2012. JAMA. 2014; 311(8):806-14. PMC: 4770258. DOI: 10.1001/jama.2014.732. View

17.

Taveras E . Childhood Obesity Risk and Prevention: Shining a Lens on the First 1000 Days. Child Obes. 2016; 12(3):159-61. PMC: 4876524. DOI: 10.1089/chi.2016.0088. View

18.

Kalliomaki M, Collado M, Salminen S, Isolauri E . Early differences in fecal microbiota composition in children may predict overweight. Am J Clin Nutr. 2008; 87(3):534-8. DOI: 10.1093/ajcn/87.3.534. View

19.

Li R, Fein S, Grummer-Strawn L . Do infants fed from bottles lack self-regulation of milk intake compared with directly breastfed infants?. Pediatrics. 2010; 125(6):e1386-93. DOI: 10.1542/peds.2009-2549. View

20.

Bowatte G, Tham R, Allen K, Tan D, Lau M, Dai X . Breastfeeding and childhood acute otitis media: a systematic review and meta-analysis. Acta Paediatr. 2015; 104(467):85-95. DOI: 10.1111/apa.13151. View