Association of the Rs1760944 Polymorphism in the APEX1 Base Excision Repair Gene with Risk of Nasopharyngeal Carcinoma in a Population from an Endemic Area in South China

Overview

Journal J Clin Lab Anal

Publisher Wiley

Specialties Biomedical Engineering
Biotechnology
Pathology

Date 2017 May 3

PMID 28464393

Citations 6

Authors

Zhifang Lu

Sisi Li

Sisi Ning

Mengwei Yao

Xunzhao Zhou

Yuan Wu

Changtao Zhong

Kui Yan

Zhengbo Wei

Ying Xie

Affiliations

Soon will be listed here.

Abstract

Background: Apurinic/apyrimidinic endonuclease 1 (APEX1) plays a central role in the repair of oxidative DNA lesions via base excision repair, and polymorphism in the APEX1 gene may affect susceptibility to carcinogenesis.

Methods: Here, we assessed possible relationships between single-nucleotide polymorphism at APEX1 rs1760944 and risk of nasopharyngeal carcinoma (NPC) in 477 NPC patients and 558 healthy controls from Guangxi province, which is the second largest NPC endemic area in South China.

Results: Genotype frequencies in controls were in Hardy-Weinberg equilibrium. Logistic regression analysis identified the genotypes GT or GG as associated with significantly lower risk than the genotype TT (adjusted odds ratio [OR] 0.745, 95% confidence interval [CI] 0.573-0.970). This apparent protective effect of GT/GG was even greater among those with no smoking history (adjusted OR 0.679, 95%CI 0.494-0.934).

Conclusion: Our results suggest that APEX1 rs1760944 polymorphism may correlate with NPC susceptibility in a population from an endemic area in South China.

Citing Articles

Upregulation of cyclin D1 can act as an independent prognostic marker for longer survival time in human nasopharyngeal carcinoma.

Liu Y, Liu Q, Wang Z, Chen M, Chen Y, Li X J Clin Lab Anal. 2020; 34(8):e23298.

PMID: 32697404 PMC: 7439355. DOI: 10.1002/jcla.23298.

A Dual Face of APE1 in the Maintenance of Genetic Stability in Monocytes: An Overview of the Current Status and Future Perspectives.

Betlej G, Bator E, Pyrkosz A, Kwiatkowska A Genes (Basel). 2020; 11(6).

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Association between apurinic/apyrimidinic endonuclease 1 rs1760944 T>G polymorphism and susceptibility of cancer: a meta-analysis involving 21764 subjects.

Ding G, Chen Y, Pan H, Qiu H, Tang W, Chen S Biosci Rep. 2019; 39(12).

PMID: 31804681 PMC: 6923335. DOI: 10.1042/BSR20190866.

Polymorphisms and Neuroblastoma Risk in Chinese Children: A Three-Center Case-Control Study.

Liu J, Jia W, Hua R, Zhu J, Zhang J, Yang T Oxid Med Cell Longev. 2019; 2019:5736175.

PMID: 31341530 PMC: 6614964. DOI: 10.1155/2019/5736175.

Genetic association of promoter in GRP78 gene with nasopharyngeal carcinoma in a Chinese population.

Wang R, Qin H, Qin L, Wei J, Wei Y, Wang J Int J Clin Oncol. 2018; 24(4):359-365.

PMID: 30413914 DOI: 10.1007/s10147-018-1366-4.

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