Sphingosine-1-phosphate Promotes Ovarian Cancer Cell Proliferation by Disrupting Hippo Signaling

Overview

Journal Oncotarget

Specialty Oncology

Date 2017 May 3

PMID 28460443

Citations 13

Authors

Qianlan Fan

Yuan Cheng

Hsun-Ming Chang

Masashi Deguchi

Aaron J Hsueh

Peter C K Leung

Affiliations

Soon will be listed here.

Abstract

Epithelial ovarian carcinomas account for more than 90% of human ovarian cancers and have become the primary cause of death for gynecological malignancies. Unlimited cell proliferation and resistance to cell apoptosis contribute to the development of ovarian cancers. However, the underlying mechanisms involved in these processes in epithelial ovarian carcinomas are yet poorly understood. In the present study, we examined the Hippo signaling gene expression and investigated the effects of Sphingosine 1-phosphate (S1P) on cell proliferation and the underlying mechanisms in human ovarian cancer cell lines, OVCAR3 and SKOV3. Our results demonstrate that S1P disrupts Hippo signaling by reducing YAP phosphorylation and increasing the expression of CCN1 and CCN2 in both ovarian cancer cells. Furthermore, the increase in CCN1/CCN2 expression contributes to the S1P-induced increase in cancer cell proliferation.

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