Sphingosine 1-phosphate and Cancer

Overview

Journal Nat Rev Cancer

Specialty Oncology

Date 2010 Jun 18

PMID 20555359

Citations 465

Authors

Nigel J Pyne

Susan Pyne

Affiliations

Soon will be listed here.

Abstract

There is substantial evidence that sphingosine 1-phosphate (S1P) is involved in cancer. S1P regulates processes such as inflammation, which can drive tumorigenesis; neovascularization, which provides cancer cells with nutrients and oxygen; and cell growth and survival. This occurs at multiple levels and involves S1P receptors, sphingosine kinases, S1P phosphatases and S1P lyase. This Review summarizes current research findings and examines the potential for new therapeutics designed to alter S1P signalling and function in cancer.

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