CD4 and CD8 Cell Responses to Herpes Simplex Virus in Behçet's Disease

Overview

Journal Clin Exp Immunol

Publisher Oxford University Press

Specialty Allergy & Immunology

Date 1988 Jul 1

PMID 2844457

Citations 13

Authors

C Young

T Lehner

C G Barnes

Affiliations

Soon will be listed here.

Abstract

The finding of part of the Herpes simplex virus type 1 (HSV1) genome in peripheral blood leucocytes of some patients with Behcet's disease (BD) led to investigations of T cell responses to HSV1 in this disease. A significantly impaired uptake of 3H-thymidine by CD4 cells was found in BD, as compared with healthy HSV1 sero-positive subjects. The impaired cellular response appeared to be specific to HSV1, as neither cytomegalovirus nor varicella-zoster virus showed depressed CD4 cell responses in BD. A similar impairment of CD4 cell responses to HSV1 was found in patients with recurrent herpetic infections, known to be caused by latent HSV1 infections. However, in rheumatoid arthritis which was selected as an unrelated autoimmune disease. 3H-thymidine uptake by CD4 cells stimulated with HSV1 was enhanced. CD8 cells showed generally rather a low uptake of 3H-thymidine, nevertheless, the values in BD and recurrent herpetic infection were again lower than those in sero-positive controls or rheumatoid arthritis. The results are consistent with the hypothesis that HSV1 might be involved in the immunopathogenesis of BD.

Citing Articles

The role of CCR1 and therapeutic effects of anti-CCL3 antibody in herpes simplex virus-induced Behçet's disease mouse model.

Sayeed H, Lee E, Byun H, Sohn S Immunology. 2019; 158(3):206-218.

PMID: 31393598 PMC: 6797864. DOI: 10.1111/imm.13102.

Behcet disease combined with Sjogren syndrome: A unique case report and literature review.

Ju F, Xu T, Hong H, Mao H, Wang M, Wang Z Medicine (Baltimore). 2018; 97(12):e0138.

PMID: 29561414 PMC: 5895329. DOI: 10.1097/MD.0000000000010138.

Decreased serum level of antibody against human cytomegalovirus in patients with Behçet's disease.

Lee E, Kwon Y, Shin K, Song Y, Park C, Hwang E Rheumatol Int. 2003; 25(1):33-6.

PMID: 14600786 DOI: 10.1007/s00296-003-0394-0.

Human recombinant interferon alfa-2a for the treatment of Behçet's disease with sight threatening posterior or panuveitis.

Kotter I, Zierhut M, Eckstein A, Vonthein R, Ness T, Gunaydin I Br J Ophthalmol. 2003; 87(4):423-31.

PMID: 12642304 PMC: 1771623. DOI: 10.1136/bjo.87.4.423.

Treatment of ocular symptoms of Behçet's disease with interferon alpha 2a: a pilot study.

Kotter I, Eckstein A, Stubiger N, Zierhut M Br J Ophthalmol. 1998; 82(5):488-94.

PMID: 9713053 PMC: 1722610. DOI: 10.1136/bjo.82.5.488.

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