Reprogramming of Cancer Metabolism by MYC

Overview

Journal Front Cell Dev Biol

Specialty Cell Biology

Date 2017 Apr 27

PMID 28443280

Citations 37

Authors

Roman Camarda

Jeremy Williams

Andrei Goga

Affiliations

Soon will be listed here.

Abstract

The past few decades have welcomed tremendous advancements toward understanding the functional significance of altered metabolism during tumorigenesis. However, many conclusions drawn from studies of cancer cells in a dish (i.e., ) have been put into question as multiple lines of evidence have demonstrated that the metabolism of cells can differ significantly from that of primary tumors (. This realization, along with the need to identify tissue-specific vulnerabilities of driver oncogenes, has led to an increased focus on oncogene-dependent metabolic programming . The oncogene c-MYC (MYC) is overexpressed in a wide variety of human cancers, and while its ability to alter cellular metabolism is well-established, translating the metabolic requirements, and vulnerabilities of MYC-driven cancers to the clinic has been hindered by disparate findings from and models. This review will provide an overview of the strategies, mechanisms, and conclusions generated thus far by studying MYC's regulation of metabolism in various cancer models.

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References

Shachaf C, Kopelman A, Arvanitis C, Karlsson A, Beer S, Mandl S . MYC inactivation uncovers pluripotent differentiation and tumour dormancy in hepatocellular cancer. Nature. 2004; 431(7012):1112-7. DOI: 10.1038/nature03043. View

Braso-Maristany F, Filosto S, Catchpole S, Marlow R, Quist J, Francesch-Domenech E . PIM1 kinase regulates cell death, tumor growth and chemotherapy response in triple-negative breast cancer. Nat Med. 2016; 22(11):1303-1313. PMC: 5552044. DOI: 10.1038/nm.4198. View

Camarda R, Zhou A, Kohnz R, Balakrishnan S, Mahieu C, Anderton B . Inhibition of fatty acid oxidation as a therapy for MYC-overexpressing triple-negative breast cancer. Nat Med. 2016; 22(4):427-32. PMC: 4892846. DOI: 10.1038/nm.4055. View

Cao M, Lamichhane S, Lundgren S, Bofin A, Fjosne H, Giskeodegard G . Metabolic characterization of triple negative breast cancer. BMC Cancer. 2014; 14:941. PMC: 4295321. DOI: 10.1186/1471-2407-14-941. View

Intlekofer A, Dematteo R, Venneti S, Finley L, Lu C, Judkins A . Hypoxia Induces Production of L-2-Hydroxyglutarate. Cell Metab. 2015; 22(2):304-11. PMC: 4527873. DOI: 10.1016/j.cmet.2015.06.023. View

Chang C, Qiu J, OSullivan D, Buck M, Noguchi T, Curtis J . Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression. Cell. 2015; 162(6):1229-41. PMC: 4864363. DOI: 10.1016/j.cell.2015.08.016. View

Derose Y, Wang G, Lin Y, Bernard P, Buys S, Ebbert M . Tumor grafts derived from women with breast cancer authentically reflect tumor pathology, growth, metastasis and disease outcomes. Nat Med. 2011; 17(11):1514-20. PMC: 3553601. DOI: 10.1038/nm.2454. View

Matzuk M, WAKIL S . Continuous fatty acid oxidation and reduced fat storage in mice lacking acetyl-CoA carboxylase 2. Science. 2001; 291(5513):2613-6. DOI: 10.1126/science.1056843. View

Park J, Vithayathil S, Kumar S, Sung P, Dobrolecki L, Putluri V . Fatty Acid Oxidation-Driven Src Links Mitochondrial Energy Reprogramming and Oncogenic Properties in Triple-Negative Breast Cancer. Cell Rep. 2016; 14(9):2154-2165. PMC: 4809061. DOI: 10.1016/j.celrep.2016.02.004. View

10.

McKeown M, Bradner J . Therapeutic strategies to inhibit MYC. Cold Spring Harb Perspect Med. 2014; 4(10). PMC: 4200208. DOI: 10.1101/cshperspect.a014266. View

11.

Meyer N, Penn L . Reflecting on 25 years with MYC. Nat Rev Cancer. 2008; 8(12):976-90. DOI: 10.1038/nrc2231. View

12.

Cairo S, Armengol C, De Reynies A, Wei Y, Thomas E, Renard C . Hepatic stem-like phenotype and interplay of Wnt/beta-catenin and Myc signaling in aggressive childhood liver cancer. Cancer Cell. 2008; 14(6):471-84. DOI: 10.1016/j.ccr.2008.11.002. View

13.

Hanahan D, Weinberg R . Hallmarks of cancer: the next generation. Cell. 2011; 144(5):646-74. DOI: 10.1016/j.cell.2011.02.013. View

14.

Shroff E, Eberlin L, Dang V, Gouw A, Gabay M, Adam S . MYC oncogene overexpression drives renal cell carcinoma in a mouse model through glutamine metabolism. Proc Natl Acad Sci U S A. 2015; 112(21):6539-44. PMC: 4450371. DOI: 10.1073/pnas.1507228112. View

15.

Palaskas N, Larson S, Schultz N, Komisopoulou E, Wong J, Rohle D . 18F-fluorodeoxy-glucose positron emission tomography marks MYC-overexpressing human basal-like breast cancers. Cancer Res. 2011; 71(15):5164-74. PMC: 3148325. DOI: 10.1158/0008-5472.CAN-10-4633. View

16.

Huang Q, Tan Y, Yin P, Ye G, Gao P, Lu X . Metabolic characterization of hepatocellular carcinoma using nontargeted tissue metabolomics. Cancer Res. 2013; 73(16):4992-5002. DOI: 10.1158/0008-5472.CAN-13-0308. View

17.

Hart L, Cunningham J, Datta T, Dey S, Tameire F, Lehman S . ER stress-mediated autophagy promotes Myc-dependent transformation and tumor growth. J Clin Invest. 2012; 122(12):4621-34. PMC: 3533536. DOI: 10.1172/JCI62973. View

18.

Shachaf C, Perez O, Youssef S, Fan A, Elchuri S, Goldstein M . Inhibition of HMGcoA reductase by atorvastatin prevents and reverses MYC-induced lymphomagenesis. Blood. 2007; 110(7):2674-84. PMC: 1988916. DOI: 10.1182/blood-2006-09-048033. View

19.

Wang H, Lu J, Edmunds L, Kulkarni S, Dolezal J, Tao J . Coordinated Activities of Multiple Myc-dependent and Myc-independent Biosynthetic Pathways in Hepatoblastoma. J Biol Chem. 2016; 291(51):26241-26251. PMC: 5159488. DOI: 10.1074/jbc.M116.754218. View

20.

Davidson S, Papagiannakopoulos T, Olenchock B, Heyman J, Keibler M, Luengo A . Environment Impacts the Metabolic Dependencies of Ras-Driven Non-Small Cell Lung Cancer. Cell Metab. 2016; 23(3):517-28. PMC: 4785096. DOI: 10.1016/j.cmet.2016.01.007. View