The Roles and Molecular Mechanisms of Non-coding RNA in Cancer Metabolic Reprogramming

Overview

Journal Cancer Cell Int

Publisher Biomed Central

Date 2024 Jan 18

PMID 38238756

Authors

Shizhen Li

Mingjing Peng

Shiming Tan

Linda Oyang

Jinguan Lin

Longzheng Xia

Jiewen Wang

Nayiyuan Wu

Xianjie Jiang

Qiu Peng

Yujuan Zhou

Qianjin Liao

Affiliations

Soon will be listed here.

Abstract

One of the key features of cancer is energy metabolic reprogramming which is tightly related to cancer proliferation, invasion, metastasis, and chemotherapy resistance. NcRNAs are a class of RNAs having no protein-coding potential and mainly include microRNAs, lncRNAs and circRNAs. Accumulated evidence has suggested that ncRNAs play an essential role in regulating cancer metabolic reprogramming, and the altered metabolic networks mediated by ncRNAs primarily drive carcinogenesis by regulating the expression of metabolic enzymes and transporter proteins. Importantly, accumulated research has revealed that dysregulated ncRNAs mediate metabolic reprogramming contributing to the generation of therapeutic tolerance. Elucidating the molecular mechanism of ncRNAs in cancer metabolic reprogramming can provide promising metabolism-related therapeutic targets for treatment as well as overcome therapeutic tolerance. In conclusion, this review updates the latest molecular mechanisms of ncRNAs related to cancer metabolic reprogramming.

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