» Articles » PMID: 28442839

The Place of Calprotectin, Lactoferrin, and High-Mobility Group Box 1 Protein on Diagnosis of Acute Appendicitis with Children

Overview
Journal Indian J Surg
Specialty General Surgery
Date 2017 Apr 27
PMID 28442839
Citations 7
Authors
Affiliations
Soon will be listed here.
Abstract

The purpose of this study is to investigate the role of serum calprotectin (CP), lactoferrin (LF), and high-mobility group protein B1 (HMGB-1) levels and fecal CP and LF levels in differential diagnosis of acute uncomplicated appendicitis from other causes of abdominal pain and further from complicated appendicitis. Totally, 120 children were included grouped into 4 as: healthy controls, patients with right lower quadrant pain with other than surgical causes, patients with uncomplicated appendicitis, and patients with complicated appendicitis. Serum CP, LF, HMGB-1, C-reactive protein (CRP) levels, and white blood cell (WBC) count were studied as well as the fecal CP and LF levels. There was a statistically significant difference between control group and both uncomplicated and complicated acute appendicitis groups, regarding all parameters. In diagnosis of complicated acute appendicitis, area under curve (AUC) for fecal LF, serum CP, and serum HMGB-1 were determined as 1.00 and the cutoff level was determined as 25 μg/g feces, 670 ng/mL, and 30 ng/mL, respectively. In differential diagnosis of uncomplicated and complicated AA, the most accurate parameter was fecal LF with an AUC of 0.977. At a 60 μg/g cutoff value for this variable, sensitivity, specificity, and accuracy were 96.7, 93.3, and 95.0 %, respectively. In conclusion, HMGB-1, calprotectin, and lactoferrin constitute novel markers in diagnosis of AA. Moreover, their levels may be helpful for the clinicians to judge about the severity of the condition. Larger studies are warranted to determine the diagnostic potential of HMGB-1, LF, and CP in AA diagnosis.

Citing Articles

Risk factors for acute complicated appendicitis in children aged three years and younger.

Ju J, Zhang T, Cheng Y, Zhou Y, Qi S, Zhang Z BMC Pediatr. 2024; 24(1):484.

PMID: 39068388 PMC: 11282835. DOI: 10.1186/s12887-024-04959-w.


Leucine-Rich Alpha-2-Glycoprotein as a non-invasive biomarker for pediatric acute appendicitis: a systematic review and meta-analysis.

Arredondo Montero J, Perez Riveros B, Bueso Asfura O, Rico Jimenez M, Lopez-Andres N, Martin-Calvo N Eur J Pediatr. 2023; 182(7):3033-3044.

PMID: 37148275 PMC: 10354117. DOI: 10.1007/s00431-023-04978-2.


Postoperative diarrhea in Crohn's disease: Pathogenesis, diagnosis, and therapy.

Wu E, Guo Z, Zhu W World J Clin Cases. 2023; 11(1):7-16.

PMID: 36687182 PMC: 9846968. DOI: 10.12998/wjcc.v11.i1.7.


Diagnostic performance of calprotectin and APPY-1 test in pediatric acute appendicitis: a systematic review and a meta-analysis.

Arredondo Montero J, Bardaji Pascual C, Antona G, Bronte Anaut M, Lopez-Andres N, Martin-Calvo N Eur J Trauma Emerg Surg. 2022; 49(2):763-773.

PMID: 35633377 DOI: 10.1007/s00068-022-02000-2.


sB7H3 in Children with Acute Appendicitis: Its Diagnostic Value and Association with Histological Findings.

Du X, Chen Y, Zhu J, Bai Z, Hua J, Li Y J Immunol Res. 2020; 2020:2670527.

PMID: 32953890 PMC: 7482032. DOI: 10.1155/2020/2670527.


References
1.
Thuijls G, Derikx J, Prakken F, Huisman B, van Bijnen Ing A, van Heurn E . A pilot study on potential new plasma markers for diagnosis of acute appendicitis. Am J Emerg Med. 2010; 29(3):256-60. DOI: 10.1016/j.ajem.2009.09.029. View

2.
Andersson R . Meta-analysis of the clinical and laboratory diagnosis of appendicitis. Br J Surg. 2004; 91(1):28-37. DOI: 10.1002/bjs.4464. View

3.
Vermeire S, Van Assche G, Rutgeerts P . Laboratory markers in IBD: useful, magic, or unnecessary toys?. Gut. 2006; 55(3):426-31. PMC: 1856093. DOI: 10.1136/gut.2005.069476. View

4.
Hu J, Wu J, Zhang L, Yang L, Long C . [Diagnostic value of high mobility group box 1 for acute appendicitis in children]. Zhongguo Dang Dai Er Ke Za Zhi. 2014; 16(9):919-21. View

5.
Langhorst J, Elsenbruch S, Koelzer J, Rueffer A, Michalsen A, Dobos G . Noninvasive markers in the assessment of intestinal inflammation in inflammatory bowel diseases: performance of fecal lactoferrin, calprotectin, and PMN-elastase, CRP, and clinical indices. Am J Gastroenterol. 2007; 103(1):162-9. DOI: 10.1111/j.1572-0241.2007.01556.x. View