Default Mode Network Subsystems Are Differentially Disrupted in Posttraumatic Stress Disorder

Overview

Journal Biol Psychiatry Cogn Neurosci Neuroimaging

Specialties Neurology
Psychiatry
Radiology

Date 2017 Apr 25

PMID 28435932

Citations 59

Authors

Danielle R Miller

Scott M Hayes

Jasmeet P Hayes

Jeffrey M Spielberg

Ginette Lafleche

Mieke Verfaellie

Affiliations

Soon will be listed here.

Abstract

Background: Posttraumatic stress disorder (PTSD) is a psychiatric disorder characterized by debilitating re-experiencing, avoidance, and hyperarousal symptoms following trauma exposure. Recent evidence suggests that individuals with PTSD show disrupted functional connectivity in the default mode network, an intrinsic network that consists of a midline core, a medial temporal lobe (MTL) subsystem, and a dorsomedial prefrontal cortex (dMPFC) subsystem. The present study examined whether functional connectivity in these subsystems is differentially disrupted in PTSD.

Methods: Sixty-nine returning war Veterans with PTSD and 44 trauma-exposed Veterans without PTSD underwent resting state functional MRI (rs-fMRI). To examine functional connectivity, seeds were placed in the core hubs of the default mode network, namely the posterior cingulate cortex (PCC) and anterior medial PFC (aMPFC), and in each subsystem.

Results: Compared to controls, individuals with PTSD had reduced functional connectivity between the PCC and the hippocampus, a region of the MTL subsystem. Groups did not differ in connectivity between the PCC and dMPFC subsystem or between the aMPFC and any region within either subsystem. In the PTSD group, connectivity between the PCC and hippocampus was negatively associated with avoidance/numbing symptoms. Examination of the MTL and dMPFC subsystems revealed reduced anticorrelation between the ventromedial PFC (vMPFC) seed of the MTL subsystem and the dorsal anterior cingulate cortex in the PTSD group.

Conclusions: Our results suggest that selective alterations in functional connectivity in the MTL subsystem of the default mode network in PTSD may be an important factor in PTSD pathology and symptomatology.

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References

Sheldon S, Levine B . Same as it ever was: vividness modulates the similarities and differences between the neural networks that support retrieving remote and recent autobiographical memories. Neuroimage. 2013; 83:880-91. DOI: 10.1016/j.neuroimage.2013.06.082. View

Sripada R, King A, Welsh R, Garfinkel S, Wang X, Sripada C . Neural dysregulation in posttraumatic stress disorder: evidence for disrupted equilibrium between salience and default mode brain networks. Psychosom Med. 2012; 74(9):904-11. PMC: 3498527. DOI: 10.1097/PSY.0b013e318273bf33. View

Jenkinson M, Bannister P, Brady M, Smith S . Improved optimization for the robust and accurate linear registration and motion correction of brain images. Neuroimage. 2002; 17(2):825-41. DOI: 10.1016/s1053-8119(02)91132-8. View

Schonfeld S, Ehlers A, Bollinghaus I, Rief W . Overgeneral memory and suppression of trauma memories in post-traumatic stress disorder. Memory. 2007; 15(3):339-52. DOI: 10.1080/09658210701256571. View

Bremner J, Narayan M, Staib L, Southwick S, McGlashan T, Charney D . Neural correlates of memories of childhood sexual abuse in women with and without posttraumatic stress disorder. Am J Psychiatry. 1999; 156(11):1787-95. PMC: 3233772. DOI: 10.1176/ajp.156.11.1787. View

Phelps E, Delgado M, Nearing K, LeDoux J . Extinction learning in humans: role of the amygdala and vmPFC. Neuron. 2004; 43(6):897-905. DOI: 10.1016/j.neuron.2004.08.042. View

Williams J . Capture and rumination, functional avoidance, and executive control (CaRFAX): Three processes that underlie overgeneral memory. Cogn Emot. 2015; 20(3-4):548-68. DOI: 10.1080/02699930500450465. View

Shin L, Liberzon I . The neurocircuitry of fear, stress, and anxiety disorders. Neuropsychopharmacology. 2009; 35(1):169-91. PMC: 3055419. DOI: 10.1038/npp.2009.83. View

Mechias M, Etkin A, Kalisch R . A meta-analysis of instructed fear studies: implications for conscious appraisal of threat. Neuroimage. 2009; 49(2):1760-8. DOI: 10.1016/j.neuroimage.2009.09.040. View

10.

Woolrich M . Robust group analysis using outlier inference. Neuroimage. 2008; 41(2):286-301. DOI: 10.1016/j.neuroimage.2008.02.042. View

11.

Sadeh N, Spielberg J, Warren S, Miller G, Heller W . Aberrant Neural Connectivity during Emotional Processing Associated with Posttraumatic Stress. Clin Psychol Sci. 2014; 2(6):748-755. PMC: 4238937. DOI: 10.1177/2167702614530113. View

12.

Eklund A, Nichols T, Knutsson H . Cluster failure: Why fMRI inferences for spatial extent have inflated false-positive rates. Proc Natl Acad Sci U S A. 2016; 113(28):7900-5. PMC: 4948312. DOI: 10.1073/pnas.1602413113. View

13.

Pitman R, Rasmusson A, Koenen K, Shin L, Orr S, Gilbertson M . Biological studies of post-traumatic stress disorder. Nat Rev Neurosci. 2012; 13(11):769-87. PMC: 4951157. DOI: 10.1038/nrn3339. View

14.

Liberzon I, Sripada C . The functional neuroanatomy of PTSD: a critical review. Prog Brain Res. 2007; 167:151-69. DOI: 10.1016/S0079-6123(07)67011-3. View

15.

Ono M, Devilly G, Shum D . A meta-analytic review of overgeneral memory: The role of trauma history, mood, and the presence of posttraumatic stress disorder. Psychol Trauma. 2015; 8(2):157-64. DOI: 10.1037/tra0000027. View

16.

Addis D, McIntosh A, Moscovitch M, Crawley A, McAndrews M . Characterizing spatial and temporal features of autobiographical memory retrieval networks: a partial least squares approach. Neuroimage. 2004; 23(4):1460-71. DOI: 10.1016/j.neuroimage.2004.08.007. View

17.

Etkin A, Egner T, Kalisch R . Emotional processing in anterior cingulate and medial prefrontal cortex. Trends Cogn Sci. 2010; 15(2):85-93. PMC: 3035157. DOI: 10.1016/j.tics.2010.11.004. View

18.

Milad M, Pitman R, Ellis C, Gold A, Shin L, Lasko N . Neurobiological basis of failure to recall extinction memory in posttraumatic stress disorder. Biol Psychiatry. 2009; 66(12):1075-82. PMC: 2787650. DOI: 10.1016/j.biopsych.2009.06.026. View

19.

Douglas Bremner J, Vermetten E, Schmahl C, Vaccarino V, Vythilingam M, Afzal N . Positron emission tomographic imaging of neural correlates of a fear acquisition and extinction paradigm in women with childhood sexual-abuse-related post-traumatic stress disorder. Psychol Med. 2005; 35(6):791-806. PMC: 3233760. DOI: 10.1017/s0033291704003290. View

20.

Koch S, van Zuiden M, Nawijn L, Frijling J, Veltman D, Olff M . ABERRANT RESTING-STATE BRAIN ACTIVITY IN POSTTRAUMATIC STRESS DISORDER: A META-ANALYSIS AND SYSTEMATIC REVIEW. Depress Anxiety. 2016; 33(7):592-605. DOI: 10.1002/da.22478. View