The Multiscale Topological Organization of the Functional Brain Network in Adolescent PTSD

Overview

Journal Cereb Cortex

Publisher Oxford University Press

Specialty Neurology

Date 2024 Jun 12

PMID 38864573

Authors

David Corredor

Shailendra Segobin

Thomas Hinault

Francis Eustache

Jacques Dayan

Berengere Guillery-Girard

Mikael Naveau

Affiliations

Soon will be listed here.

Abstract

The experience of an extremely aversive event can produce enduring deleterious behavioral, and neural consequences, among which posttraumatic stress disorder (PTSD) is a representative example. Although adolescence is a period of great exposure to potentially traumatic events, the effects of trauma during adolescence remain understudied in clinical neuroscience. In this exploratory work, we aim to study the whole-cortex functional organization of 14 adolescents with PTSD using a data-driven method tailored to our population of interest. To do so, we built on the network neuroscience framework and specifically on multilayer (multisubject) community analysis to study the functional connectivity of the brain. We show, across different topological scales (the number of communities composing the cortex), a hyper-colocalization between regions belonging to occipital and pericentral regions and hypo-colocalization in middle temporal, posterior-anterior medial, and frontal cortices in the adolescent PTSD group compared to a nontrauma exposed group of adolescents. These preliminary results raise the question of an altered large-scale cortical organization in adolescent PTSD, opening an interesting line of research for future investigations.

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