Self-Assembled Bifunctional Peptide As Effective Drug Delivery Vector with Powerful Antitumor Activity

Overview

Journal Adv Sci (Weinh)

Specialty Biomedical Engineering

Date 2017 Apr 25

PMID 28435772

Citations 7

Authors

Rangrang Fan

Lan Mei

Xiang Gao

Yuelong Wang

Mingli Xiang

Yu Zheng

Aiping Tong

Xiaoning Zhang

Bo Han

Liangxue Zhou

Peng Mi

Chao You

Zhiyong Qian

Yuquan Wei

Gang Guo

Affiliations

Soon will be listed here.

Abstract

E-cadherin/catenin complex is crucial for cancer cell migration and invasion. The histidine-alanine-valine (HAV) sequence has been shown to inhibit a variety of cadherin-based functions. In this study, by fusing HAV and the classical tumor-targeting Arg-Gly-Asp (RGD) motif and Asn-Gly-Arg (NGR) motif to the apoptosis-inducing peptide sequence-AVPIAQK, a bifunctional peptide has been constructed with enhanced tumor targeting and apoptosis effects. This peptide is further processed as a nanoscale vector to encapsulate the hydrophobic drug docetaxel (DOC). Bioimaging analysis shows that peptide nanoparticles can penetrate into xenograft tumor cells with a significantly long retention in tumors and high tumor targeting specificity. In vivo, DOC/peptide NPs are substantially more effective at inhibiting tumor growth and prolonging survival compared with DOC control. Together, the findings of this study suggest that DOC/peptide NPs may have promising applications in pulmonary carcinoma therapy.

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