RNA-binding Proteins in Human Oogenesis: Balancing Differentiation and Self-renewal in the Female Fetal Germline

Overview

Journal Stem Cell Res

Publisher Elsevier

Specialty Cell Biology

Date 2017 Apr 25

PMID 28434825

Citations 12

Authors

Roseanne Rosario

Andrew J Childs

Richard A Anderson

Affiliations

Soon will be listed here.

Abstract

Primordial germ cells undergo three significant processes on their path to becoming primary oocytes: the initiation of meiosis, the formation and breakdown of germ cell nests, and the assembly of single oocytes into primordial follicles. However at the onset of meiosis, the germ cell becomes transcriptionally silenced. Consequently translational control of pre-stored mRNAs plays a central role in coordinating gene expression throughout the remainder of oogenesis; RNA binding proteins are key to this regulation. In this review we examine the role of exemplars of such proteins, namely LIN28, DAZL, BOLL and FMRP, and highlight how their roles during germ cell development are critical to oogenesis and the establishment of the primordial follicle pool.

Citing Articles

ADR-2 regulates fertility and oocyte fate in Caenorhabditis elegans.

Erdmann E, Forbes M, Becker M, Perez S, Hundley H Genetics. 2024; 228(2).

PMID: 39028799 PMC: 11457940. DOI: 10.1093/genetics/iyae114.

Loss of FMRP affects ovarian development and behaviour through multiple pathways in a zebrafish model of fragile X syndrome.

Rani R, Sri N, Medishetti R, Chatti K, Sevilimedu A Hum Mol Genet. 2024; 33(16):1391-1405.

PMID: 38710511 PMC: 7616351. DOI: 10.1093/hmg/ddae077.

ADR-2 regulates fertility and oocyte fate in .

Erdmann E, Forbes M, Becker M, Perez S, Hundley H bioRxiv. 2023; .

PMID: 37961348 PMC: 10635048. DOI: 10.1101/2023.11.01.565157.

Making a good egg: human oocyte health, aging, and in vitro development.

Telfer E, Grosbois J, Odey Y, Rosario R, Anderson R Physiol Rev. 2023; 103(4):2623-2677.

PMID: 37171807 PMC: 10625843. DOI: 10.1152/physrev.00032.2022.

The APC/C Complex Coordinates With OMA-1 to Regulate the Oocyte-to-Embryo Transition in .

Hu Y, Hu X, Li D, Du Z, Shi K, He C Front Cell Dev Biol. 2021; 9:749654.

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