ALDH1A1 Provides a Source of Meiosis-inducing Retinoic Acid in Mouse Fetal Ovaries

Overview

Journal Nat Commun

Specialty Biology

Date 2016 Feb 20

PMID 26892828

Citations 34

Authors

Josephine Bowles

Chun-Wei Feng

Kim Miles

Jessica Ineson

Cassy Spiller

Peter Koopman

Affiliations

Soon will be listed here.

Abstract

Substantial evidence exists that during fetal ovarian development in mammals, retinoic acid (RA) induces germ cells to express the pre-meiotic marker Stra8 and enter meiosis, and that these effects are prevented in the fetal testis by the RA-degrading P450 enzyme CYP26B1. Nonetheless, the role of RA has been disputed principally because germ cells in embryos lacking two major RA-synthesizing enzymes, ALDH1A2 and ALDH1A3, remain able to enter meiosis. Here we show that a third RA-synthesizing enzyme, ALDH1A1, is expressed in fetal ovaries, providing a likely source of RA in the absence of ALDH1A2 and ALDH1A3. In ovaries lacking ALDH1A1, the onset of germ cell meiosis is delayed. Our data resolve the conundrum posed by conflicting published data sets and reconfirm the model that meiosis is triggered by endogenous RA in the developing ovary.

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