Tissue Adaptation: Implications for Gut Immunity and Tolerance

Overview

Journal J Exp Med

Specialties Allergy & Immunology
General Medicine

Date 2017 Apr 23

PMID 28432200

Citations 35

Authors

Ana M C Faria

Bernardo S Reis

Daniel Mucida

Affiliations

Soon will be listed here.

Abstract

Tissue adaptation is an intrinsic component of immune cell development, influencing both resistance to pathogens and tolerance. Chronically stimulated surfaces of the body, in particular the gut mucosa, are the major sites where immune cells traffic and reside. Their adaptation to these environments requires constant discrimination between natural stimulation coming from harmless microbiota and food, and pathogens that need to be cleared. This review will focus on the adaptation of lymphocytes to the gut mucosa, a highly specialized environment that can help us understand the plasticity of leukocytes arriving at various tissue sites and how tissue-related factors operate to shape immune cell fate and function.

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