Transiently Antigen-primed B Cells Return to Naive-like State in Absence of T-cell Help

Overview

Journal Nat Commun

Specialty Biology

Date 2017 Apr 22

PMID 28429719

Citations 21

Authors

Jackson S Turner

Matangi Marthi

Zachary L Benet

Irina Grigorova

Affiliations

Soon will be listed here.

Abstract

The perspective that naive B-cell recognition of antigen in the absence of T-cell help causes cell death or anergy is supported by in vivo studies of B cells that are continuously exposed to self-antigens. However, intravital imaging suggests that early B-cell recognition of large foreign antigens may be transient. Whether B cells are tolerized or can be recruited into humoural immune responses following such encounters is not clear. Here we show that in the presence of T-cell help, single transient antigen acquisition is sufficient to recruit B cells into the germinal centre and induce memory and plasma cell responses. In the absence of T-cell help, transiently antigen-primed B cells do not undergo apoptosis in vivo; they return to quiescence and are recruited efficiently into humoural responses upon reacquisition of antigen and T-cell help.

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