Human Immunodeficiency Virus Type 1 Has an Additional Coding Sequence in the Central Region of the Genome

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 1988 Sep 1

PMID 2842797

Citations 25

Authors

Z Matsuda

M J Chou

M Matsuda

J H Huang

Y M Chen

R Redfield

K Mayer

M Essex

T H Lee

Affiliations

Soon will be listed here.

Abstract

Eight coding regions designated gag, pol, env, sor, R, tat, art/trs, and 3' orf have been identified in the genome of the human immunodeficiency virus type 1 (HIV-1). Several other open reading frames have the potential to encode additional viral proteins. In this study, we show that HIV-1 has another coding sequence whose product is expressed during natural infection. Unlike antibody to other HIV-1 proteins, the prevalence of antibody to the product encoded by this region is elevated in patients with acquired immune deficiency syndrome (AIDS). Because no analogous coding region has been identified in HIV-2, the antibody to the product of this coding region may serve as a marker to distinguish infection with HIV-1 from infection with HIV-2.

Citing Articles

Making Sense of Multifunctional Proteins: Human Immunodeficiency Virus Type 1 Accessory and Regulatory Proteins and Connections to Transcription.

Faust T, Binning J, Gross J, Frankel A Annu Rev Virol. 2017; 4(1):241-260.

PMID: 28961413 PMC: 5750048. DOI: 10.1146/annurev-virology-101416-041654.

Genetic characterization of natural variants of Vpu from HIV-1 infected individuals from Northern India and their impact on virus release and cell death.

Verma S, Ronsard L, Kapoor R, Banerjea A PLoS One. 2013; 8(3):e59283.

PMID: 23555649 PMC: 3610703. DOI: 10.1371/journal.pone.0059283.

Open reading frame 8a of the human severe acute respiratory syndrome coronavirus not only promotes viral replication but also induces apoptosis.

Chen C, Ping Y, Lee H, Chen K, Lee Y, Chan Y J Infect Dis. 2007; 196(3):405-15.

PMID: 17597455 PMC: 7204190. DOI: 10.1086/519166.

Correlation of the structural and functional domains in the membrane protein Vpu from HIV-1.

Marassi F, Ma C, Gratkowski H, Straus S, Strebel K, Montal M Proc Natl Acad Sci U S A. 1999; 96(25):14336-41.

PMID: 10588706 PMC: 24437. DOI: 10.1073/pnas.96.25.14336.

Production of uninfectious human immunodeficiency virus type 1 containing viral protein R fused to a single-chain antibody against viral integrase.

Okui N, Kobayashi N, Kitamura Y J Virol. 1998; 72(8):6960-4.

PMID: 9658154 PMC: 109914. DOI: 10.1128/JVI.72.8.6960-6964.1998.

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