A Highly Active Manganese Catalyst for Enantioselective Ketone and Ester Hydrogenation

Overview

Journal Angew Chem Int Ed Engl

Specialty Chemistry

Date 2017 Apr 21

PMID 28425169

Citations 25

Authors

Magnus B Widegren

Gavin J Harkness

Alexandra M Z Slawin

David B Cordes

Matthew L Clarke

Affiliations

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Abstract

A new hydrogenation catalyst based on a manganese complex of a chiral P,N,N ligand has been found to be especially active for the hydrogenation of esters down to 0.1 mol % catalyst loading, and gives up to 97 % ee in the hydrogenation of pro-chiral deactivated ketones at 30-50 °C.

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