Subventricular Zones: New Key Targets for Glioblastoma Treatment

Overview

Journal Radiat Oncol

Publisher Biomed Central

Specialties Oncology
Radiology

Date 2017 Apr 21

PMID 28424082

Citations 23

Authors

J Khalifa

F Tensaouti

A Lusque

B Plas

J-A Lotterie

A Benouaich-Amiel

E Uro-Coste

V Lubrano

E Cohen-Jonathan Moyal

Affiliations

Soon will be listed here.

Abstract

Background: We aimed to identify subventricular zone (SVZ)-related prognostic factors of survival and patterns of recurrence among patients with glioblastoma.

Methods: Forty-three patients with primary diagnosed glioblastoma treated in our Cancer Center between 2006 and 2010 were identified. All patients received surgical resection, followed by temozolomide-based chemoradiation. Ipsilateral (iSVZ), contralateral (cSVZ) and bilateral (bSVZ) SVZs were retrospectively segmented and radiation dose-volume histograms were generated. Multivariate analysis using the Cox proportional hazards model was assessed to examine the relationship between prognostic factors and time to progression (TTP) or overall survival (OS).

Results: Median age was 59 years (range: 25-85). Median follow-up, OS and TTP were 22.7 months (range 7.5-69.7 months), 22.7 months (95% CI 14.5-26.2 months) and 6.4 months (95% CI 4.4-9.3 months), respectively. On univariate analysis, initial contact to SVZ was a poor prognostic factor for OS (18.7 vs 41.7 months, p = 0.014) and TTP (4.6 vs 12.9 months, p = 0.002). Patients whose bSVZ volume receiving at least 20 Gy (V20Gy) was greater than 84% had a significantly improved TTP (17.7 months vs 5.2 months, p = 0.017). This radiation dose coverage was compatible with an hippocampal sparing. On multivariate analysis, initial contact to SVZ and V20 Gy to bSVZ lesser than 84% remained poor prognostic factors for TTP (HR = 3.07, p = 0.012 and HR = 2.67, p = 0.047, respectively).

Conclusion: Our results suggest that contact to SVZ, as well as insufficient bSVZ radiation dose coverage (V20Gy <84%), might be independent poor prognostic factors for TTP. Therefore, targeting SVZ could be of crucial interest for optimizing glioblastoma treatment.

Citing Articles

Therapeutic and prognostic impact of target volume delineation in postoperative radiotherapy for high-grade glioma patients with subventricular zone involvement.

Sun F, Zhu Y, Gan G, Xu Y, Xu X Radiat Oncol. 2025; 20(1):24.

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Advanced imaging reveals enhanced malignancy in glioblastomas involving the subventricular zone: evidence of increased infiltrative growth and perfusion.

Griessmair M, Schramm S, Ziegenfeuter J, Canisius J, Jung K, Delbridge C J Neurooncol. 2024; 171(2):343-350.

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Prognostic analysis and nomogram construction for older patients with IDH-wild-type glioblastoma.

Cao W, Xiong L, Meng L, Li Z, Hu Z, Lei H Heliyon. 2023; 9(7):e18310.

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Llorente V, Velarde P, Desco M, Gomez-Gaviro M Cells. 2022; 11(19).

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The Glycoprotein M6a Is Associated with Invasiveness and Radioresistance of Glioblastoma Stem Cells.

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