The Impact of Atosiban on Pregnancy Outcomes in Women Undergoing in Vitro Fertilization-embryo Transfer: A Meta-analysis

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2017 Apr 20

PMID 28422984

Citations 12

Authors

Qian-Yi Huang

Min-Hua Rong

Ai-Hua Lan

Xiao-Miao Lin

Xing-Gu Lin

Rong-Quan He

Gang Chen

Mu-Jun Li

Affiliations

Soon will be listed here.

Abstract

Background: Atosiban is administered to women undergoing in vitro fertilization-embryo transfer (IVF-ET) to improve pregnancy outcomes. However, the results of this treatment were controversial. We conducted this meta-analysis to investigate whether atosiban improves pregnancy outcomes in the women undergoing in vitro fertilization (IVF).

Methods: Databases of PubMed, EMBASE, Web of Science, China BioMedicine, and Google Scholar were systematically searched. Meta-analyses were performed to investigate whether atosiban improves pregnancy outcomes in the women undergoing IVF.

Results: Our results showed that atosiban was associated with higher implantation (OR = 1.63, 95% CI: 1.17-2.27; P = 0.004) and clinical pregnancy (OR = 1.84, 95% CI: 1.31-2.57; P < 0.001) rates. However, atosiban showed no significant association with the miscarriage, live birth, multiple pregnancy or ectopic pregnancy rates. When a further subgroup analysis was performed in the women undergoing repeated implantation failure (RIF), implantation (OR = 1.93, 95% CI: 1.45-2.57; P < 0.001), clinical pregnancy (OR = 2.48, 95% CI: 1.70-3.64; P <0.001) and the live birth (OR = 2.89, 95% CI: 1.78-4.67; P < 0.001) rates were significantly higher in the case group. Nevertheless, no significant difference was detected in the miscarriage and multiple pregnancy rates between the case and control groups.

Conclusion: Atosiban may be more appropriate for women undergoing RIF and play only a limited role in improving pregnancy outcomes in the general population of women undergoing IVF. These conclusions should be verified in large and well-designed studies.

Citing Articles

Treatment Effects in Randomized and Nonrandomized Studies of Pharmacological Interventions: A Meta-Analysis.

Salcher-Konrad M, Nguyen M, Savovic J, Higgins J, Naci H JAMA Netw Open. 2024; 7(9):e2436230.

PMID: 39331390 PMC: 11437387. DOI: 10.1001/jamanetworkopen.2024.36230.

Effects of atosiban on clinical outcome in frozen-thawed embryo transfer: a propensity score matching study.

Ge C, Zhang B, Mao Y, Hong Z, Zhou C, Wang Y Arch Gynecol Obstet. 2024; 309(3):1101-1106.

PMID: 38240770 DOI: 10.1007/s00404-023-07289-x.

Effectiveness of atosiban in women with previous single implantation failure undergoing frozen-thawed blastocyst transfer: study protocol for a randomised controlled trial.

Cai H, Liu S, Chen L, Xie J, Yang C, Li W BMJ Open. 2023; 13(10):e076390.

PMID: 37844983 PMC: 10582862. DOI: 10.1136/bmjopen-2023-076390.

Efficacy of atosiban for repeated implantation failure in frozen embryo transfer cycles.

Li X, Du Y, Han X, Wang H, Sheng Y, Lian F Sci Rep. 2023; 13(1):9277.

PMID: 37286752 PMC: 10247710. DOI: 10.1038/s41598-023-36286-y.

Is glucocorticoid use associated with a higher clinical pregnancy rate of fertilization and embryo transfer? A meta-analysis.

Lv Y, Chen Y, Hu L, Ding H, Liu M, Li H Heliyon. 2023; 9(5):e15833.

PMID: 37215803 PMC: 10196514. DOI: 10.1016/j.heliyon.2023.e15833.

References

Pierzynski P . Oxytocin and vasopressin V(1A) receptors as new therapeutic targets in assisted reproduction. Reprod Biomed Online. 2010; 22(1):9-16. DOI: 10.1016/j.rbmo.2010.09.015. View

Zhang Y, Li M, Xiao F, Teng R, Zhang C, Lan A . Impact of partial DAZ1/2 deletion and partial DAZ3/4 deletion on male infertility. Gene. 2015; 571(1):9-16. DOI: 10.1016/j.gene.2015.07.083. View

Li J, Chen Y, Liu C, Hu Y, Li L . Intravenous immunoglobulin treatment for repeated IVF/ICSI failure and unexplained infertility: a systematic review and a meta-analysis. Am J Reprod Immunol. 2013; 70(6):434-47. DOI: 10.1111/aji.12170. View

Pierzynski P, Gajda B, Smorag Z, Rasmussen A, Kuczynski W . Effect of atosiban on rabbit embryo development and human sperm motility. Fertil Steril. 2007; 87(5):1147-52. DOI: 10.1016/j.fertnstert.2006.08.089. View

Simon A, Laufer N . Assessment and treatment of repeated implantation failure (RIF). J Assist Reprod Genet. 2012; 29(11):1227-39. PMC: 3510376. DOI: 10.1007/s10815-012-9861-4. View

Spandorfer S, Goldstein J, Navarro J, Veeck L, Davis O, Rosenwaks Z . Difficult embryo transfer has a negative impact on the outcome of in vitro fertilization. Fertil Steril. 2003; 79(3):654-5. DOI: 10.1016/s0015-0282(02)04703-9. View

Chou P, Wu M, Pan H, Hung K, Chang F . Use of an oxytocin antagonist in in vitro fertilization-embryo transfer for women with repeated implantation failure: a retrospective study. Taiwan J Obstet Gynecol. 2011; 50(2):136-40. DOI: 10.1016/j.tjog.2011.04.003. View

Luo Y, Zhang X, Mo M, Tan Z, Huang L, Zhou H . High Ki-67 Immunohistochemical Reactivity Correlates With Poor Prognosis in Bladder Carcinoma: A Comprehensive Meta-Analysis with 13,053 Patients Involved. Medicine (Baltimore). 2016; 95(15):e3337. PMC: 4839831. DOI: 10.1097/MD.0000000000003337. View

Kushnir V, Vidali A, Barad D, Gleicher N . The status of public reporting of clinical outcomes in assisted reproductive technology. Fertil Steril. 2013; 100(3):736-41. DOI: 10.1016/j.fertnstert.2013.05.012. View

10.

Ferraretti A, Goossens V, Kupka M, Bhattacharya S, de Mouzon J, Castilla J . Assisted reproductive technology in Europe, 2009: results generated from European registers by ESHRE. Hum Reprod. 2013; 28(9):2318-31. DOI: 10.1093/humrep/det278. View

11.

Matorras R, Mendoza R, Exposito A, Rodriguez-Escudero F . Influence of the time interval between embryo catheter loading and discharging on the success of IVF. Hum Reprod. 2004; 19(9):2027-30. DOI: 10.1093/humrep/deh366. View

12.

Dessolle L, Darai E, Cornet D, Rouzier R, Coutant C, Mandelbaum J . Determinants of pregnancy rate in the donor oocyte model: a multivariate analysis of 450 frozen-thawed embryo transfers. Hum Reprod. 2009; 24(12):3082-9. DOI: 10.1093/humrep/dep303. View

13.

Song X, Zhao X, Bai X, Lu Y, Zhang H, Wang Y . [Application of oxytocin antagonists in thaw embryo transfer]. Zhonghua Fu Chan Ke Za Zhi. 2013; 48(9):667-70. View

14.

Park J . Issues Related to the Updated 2014 Korean Guidelines for Tuberculosis. Tuberc Respir Dis (Seoul). 2016; 79(1):1-4. PMC: 4701788. DOI: 10.4046/trd.2016.79.1.1. View

15.

Fanchin R, Righini C, Ayoubi J, Olivennes F, De Ziegler D, Frydman R . [Uterine contractions at the time of embryo transfer: a hindrance to implantation?]. Contracept Fertil Sex. 1998; 26(7-8):498-505. View

16.

Jadad A, Moore R, Carroll D, Jenkinson C, Reynolds D, Gavaghan D . Assessing the quality of reports of randomized clinical trials: is blinding necessary?. Control Clin Trials. 1996; 17(1):1-12. DOI: 10.1016/0197-2456(95)00134-4. View

17.

Lan V, Khang V, Nhu G, Tuong H . Atosiban improves implantation and pregnancy rates in patients with repeated implantation failure. Reprod Biomed Online. 2012; 25(3):254-60. DOI: 10.1016/j.rbmo.2012.05.014. View

18.

Cohen J, Trounson A, Dawson K, Jones H, Hazekamp J, Nygren K . The early days of IVF outside the UK. Hum Reprod Update. 2005; 11(5):439-59. DOI: 10.1093/humupd/dmi016. View

19.

Ng E, Li R, Chen L, Lan V, Tuong H, Quan S . A randomized double blind comparison of atosiban in patients undergoing IVF treatment. Hum Reprod. 2014; 29(12):2687-94. DOI: 10.1093/humrep/deu263. View

20.

Moraloglu O, Tonguc E, Var T, Zeyrek T, Batioglu S . Treatment with oxytocin antagonists before embryo transfer may increase implantation rates after IVF. Reprod Biomed Online. 2010; 21(3):338-43. DOI: 10.1016/j.rbmo.2010.04.009. View