Assessment and Treatment of Repeated Implantation Failure (RIF)

Overview

Journal J Assist Reprod Genet

Publisher Springer

Specialties Genetics
Reproductive Medicine

Date 2012 Sep 15

PMID 22976427

Citations 87

Authors

Alex Simon

Neri Laufer

Affiliations

Soon will be listed here.

Abstract

Repeated implantation failure (RIF) is determined when embryos of good quality fail to implant following several in vitro fertilization (IVF) treatment cycles. Implantation failure is related to either maternal factors or embryonic causes. Maternal factors include uterine anatomic abnormalities, thrombophilia, non-receptive endometrium and immunological factors. Failure of implantation due to embryonic causes is associated with either genetic abnormalities or other factors intrinsic to the embryo that impair its ability to develop in utero, to hatch and to implant. New methods of time-lapse imaging of embryos and assessment of their metabolic functions may improve selection of embryos for transfer, and subsequent outcomes for IVF patients, as well as for those diagnosed with RIF. This review discusses the various causes associated with RIF and addresses appropriate treatments.

Citing Articles

Anti-Adhesive Podocalyxin Expression Is Disrupted in Recurrent Implantation Failure.

Tas M Diagnostics (Basel). 2025; 15(1.

PMID: 39795629 PMC: 11719751. DOI: 10.3390/diagnostics15010100.

Plasma Cells as the Key Players of IVF Failure? Unlocking the Enigma of Infertility and In Vitro Fertilization Failure in the Light of Uterine Inflammation.

Dwojak E, Mroczek M, Dworacki G, Dobosz P, Slubowska A, Stepien M Int J Mol Sci. 2024; 25(23).

PMID: 39684794 PMC: 11642339. DOI: 10.3390/ijms252313083.

Altered Expression of and Genes in the Endometrium of Patients with Recurrent Implantation Failure after In Vitro Fertilization and Thin Endometrium.

Kurmanova G, Ashirbekov Y, Kurmanova A, Mamedaliyeva N, Moshkalova G, Anartayeva G Diagnostics (Basel). 2024; 14(17).

PMID: 39272751 PMC: 11394423. DOI: 10.3390/diagnostics14171967.

Negative effects of ethanol on ovarian reserve and endometrium thickness: An animal study.

Karaman E, Ayag M Turk J Obstet Gynecol. 2024; 21(3):175-179.

PMID: 39228219 PMC: 11589319. DOI: 10.4274/tjod.galenos.2024.89439.

Differential expression of ion channel coding genes in the endometrium of women experiencing recurrent implantation failures.

Davoodi Nik B, Hashemi Karoii D, Favaedi R, Ramazanali F, Jahangiri M, Movaghar B Sci Rep. 2024; 14(1):19822.

PMID: 39192025 PMC: 11349755. DOI: 10.1038/s41598-024-70778-9.

References

Sher G, Herbert C, Maassarani G, JACOBS M . Assessment of the late proliferative phase endometrium by ultrasonography in patients undergoing in-vitro fertilization and embryo transfer (IVF/ET). Hum Reprod. 1991; 6(2):232-7. DOI: 10.1093/oxfordjournals.humrep.a137312. View

Sanders B . Uterine factors and infertility. J Reprod Med. 2006; 51(3):169-76. View

Hambartsoumian E . Endometrial leukemia inhibitory factor (LIF) as a possible cause of unexplained infertility and multiple failures of implantation. Am J Reprod Immunol. 1998; 39(2):137-43. DOI: 10.1111/j.1600-0897.1998.tb00345.x. View

Carp H, Toder V, Mashiach S, Rabinovici J . Effect of paternal leukocyte immunization on implantation after biochemical pregnancies and repeated failure of embryo transfer. Am J Reprod Immunol. 1994; 31(2-3):112-5. DOI: 10.1111/j.1600-0897.1994.tb00855.x. View

Grandone E, Colaizzo D, Lo Bue A, Checola M, Cittadini E, Margaglione M . Inherited thrombophilia and in vitro fertilization implantation failure. Fertil Steril. 2001; 76(1):201-2. DOI: 10.1016/s0015-0282(01)01832-5. View

Check J . The importance of sonographic endometrial parameters in influencing success following embryo transfer in the modern era and therapeutic options--part 1: the importance of late proliferative phase endometrial thickness. Clin Exp Obstet Gynecol. 2011; 38(3):197-200. View

Noyes N, Liu H, Sultan K, Schattman G, Rosenwaks Z . Endometrial thickness appears to be a significant factor in embryo implantation in in-vitro fertilization. Hum Reprod. 1995; 10(4):919-22. DOI: 10.1093/oxfordjournals.humrep.a136061. View

Khalifa E, Brzyski R, Oehninger S, Acosta A, Muasher S . Sonographic appearance of the endometrium: the predictive value for the outcome of in-vitro fertilization in stimulated cycles. Hum Reprod. 1992; 7(5):677-80. DOI: 10.1093/oxfordjournals.humrep.a137718. View

. Salpingectomy for hydrosalpinx prior to in vitro fertilization. Fertil Steril. 2008; 90(5 Suppl):S66-8. DOI: 10.1016/j.fertnstert.2008.08.089. View

10.

Elram T, Simon A, Israel S, Revel A, Shveiky D, Laufer N . Treatment of recurrent IVF failure and human leukocyte antigen similarity by intravenous immunoglobulin. Reprod Biomed Online. 2006; 11(6):745-9. DOI: 10.1016/s1472-6483(10)61694-x. View

11.

Obruca A, Strohmer H, Sakkas D, Menezo Y, Kogosowski A, Barak Y . Use of lasers in assisted fertilization and hatching. Hum Reprod. 1994; 9(9):1723-6. DOI: 10.1093/oxfordjournals.humrep.a138781. View

12.

Habana A, Palter S . Is tubal embryo transfer of any value? A meta-analysis and comparison with the Society for Assisted Reproductive Technology database. Fertil Steril. 2001; 76(2):286-93. DOI: 10.1016/s0015-0282(01)01879-9. View

13.

Oliveira J, Cavagna M, Petersen C, Mauri A, Massaro F, Silva L . Pregnancy outcomes in women with repeated implantation failures after intracytoplasmic morphologically selected sperm injection (IMSI). Reprod Biol Endocrinol. 2011; 9:99. PMC: 3156729. DOI: 10.1186/1477-7827-9-99. View

14.

. The role of assisted hatching in in vitro fertilization: a review of the literature. A Committee opinion. Fertil Steril. 2008; 90(5 Suppl):S196-8. DOI: 10.1016/j.fertnstert.2008.08.043. View

15.

Benkhalifa M, Demirol A, Sari T, Balashova E, Tsouroupaki M, Giakoumakis Y . Autologous embryo-cumulus cells co-culture and blastocyst transfer in repeated implantation failures: a collaborative prospective randomized study. Zygote. 2011; 20(2):173-80. DOI: 10.1017/S0967199411000062. View

16.

Schlahsa L, Jaimes Y, Blasczyk R, Figueiredo C . Granulocyte-colony-stimulatory factor: a strong inhibitor of natural killer cell function. Transfusion. 2010; 51(2):293-305. DOI: 10.1111/j.1537-2995.2010.02820.x. View

17.

Urman B, Yakin K, Balaban B . Recurrent implantation failure in assisted reproduction: how to counsel and manage. B. Treatment options that have not been proven to benefit the couple. Reprod Biomed Online. 2005; 11(3):382-91. DOI: 10.1016/s1472-6483(10)60847-4. View

18.

Virro M, Larson-Cook K, Evenson D . Sperm chromatin structure assay (SCSA) parameters are related to fertilization, blastocyst development, and ongoing pregnancy in in vitro fertilization and intracytoplasmic sperm injection cycles. Fertil Steril. 2004; 81(5):1289-95. DOI: 10.1016/j.fertnstert.2003.09.063. View

19.

Balaban B, Yakin K, Alatas C, Oktem O, Isiklar A, Urman B . Clinical outcome of intracytoplasmic injection of spermatozoa morphologically selected under high magnification: a prospective randomized study. Reprod Biomed Online. 2011; 22(5):472-6. DOI: 10.1016/j.rbmo.2010.11.003. View

20.

Harper J, SenGupta S . Preimplantation genetic diagnosis: state of the art 2011. Hum Genet. 2011; 131(2):175-86. DOI: 10.1007/s00439-011-1056-z. View