Increasing Macrolide and Fluoroquinolone Resistance in Mycoplasma Genitalium

Overview

Journal Emerg Infect Dis

Specialty Infectious Diseases

Date 2017 Apr 19

PMID 28418319

Citations 66

Authors

Gerald L Murray

Catriona S Bradshaw

Melanie Bissessor

Jennifer Danielewski

Suzanne M Garland

Jorgen S Jensen

Christopher K Fairley

Sepehr N Tabrizi

Affiliations

Soon will be listed here.

Abstract

Escalating resistance to azithromycin and moxifloxacin is being reported for Mycoplasma genitalium in the Asia-Pacific region. Analyzing 140 infections, we found pretreatment fluoroquinolone-resistance mutations in parC (13.6%) and gyrA (5%). ParC S83 changes were associated with moxifloxacin failure. Combined macrolide/fluoroquinolone-resistance mutations were in 8.6% of specimens, for which recommended therapies would be ineffective.

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