Resonance Assignments of Non-exchangeable Protons in B Type DNA Oligomers, an Overview

Overview

Journal Nucleic Acids Res

Publisher Oxford University Press

Specialty Biochemistry

Date 1988 Jul 11

PMID 2840632

Citations 6

Authors

F J van de Ven

C W Hilbers

Affiliations

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Abstract

The chemical shifts of 1H resonances of non exchangeable protons (except H5', H5" and adenine H2) of over six hundred nucleotides have been collected. The influence which the base of the nucleotide itself as well as the bases on its 5' and 3' side exert on the chemical shifts of the various resonances has been investigated. Most of the resonances appear to be predominantly influenced by only one base. For H2', H2", H3', H4' and H6/H8 this is the base of the central nucleotide, for H5(C) and CH3(T) it is the one on the 5' side and for H1' it is the one on the 3' side. Chemical shift distribution profiles are presented which allow an estimation of the probability of finding a particular resonance at a particular position in the spectrum.

Citing Articles

Analysis of (1)H chemical shifts in DNA: Assessment of the reliability of (1)H chemical shift calculations for use in structure refinement.

Wijmenga S, Kruithof M, Hilbers C J Biomol NMR. 2010; 10(4):337-50.

PMID: 20859781 DOI: 10.1023/A:1018348123074.

Highly diastereoselective synthesis of nucleoside adducts from the carcinogenic benzo[a]pyrene diol epoxide and a computational analysis.

Lakshman M, Keeler J, Ngassa F, Hilmer J, Pradhan P, Zajc B J Am Chem Soc. 2007; 129(1):68-76.

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The role of the phosphorus BI-BII transition in protein-DNA recognition: the NF-kappaB complex.

Wecker K, Bonnet M, Meurs E, Delepierre M Nucleic Acids Res. 2002; 30(20):4452-9.

PMID: 12384592 PMC: 137123. DOI: 10.1093/nar/gkf559.

Prediction of proton chemical shifts in RNA. Their use in structure refinement and validation.

Cromsigt J, Hilbers C, Wijmenga S J Biomol NMR. 2001; 21(1):11-29.

PMID: 11693565 DOI: 10.1023/a:1011914132531.

Calibration of ring-current effects in proteins and nucleic acids.

Case D J Biomol NMR. 1995; 6(4):341-6.

PMID: 8563464 DOI: 10.1007/BF00197633.

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