Gas Fermentation: Cellular Engineering Possibilities and Scale Up

Overview

Journal Microb Cell Fact

Publisher Biomed Central

Specialties Biotechnology
Microbiology

Date 2017 Apr 14

PMID 28403896

Citations 16

Authors

Bjorn D Heijstra

Ching Leang

Alex Juminaga

Affiliations

Soon will be listed here.

Abstract

Low carbon fuels and chemicals can be sourced from renewable materials such as biomass or from industrial and municipal waste streams. Gasification of these materials allows all of the carbon to become available for product generation, a clear advantage over partial biomass conversion into fermentable sugars. Gasification results into a synthesis stream (syngas) containing carbon monoxide (CO), carbon dioxide (CO), hydrogen (H) and nitrogen (N). Autotrophy-the ability to fix carbon such as CO is present in all domains of life but photosynthesis alone is not keeping up with anthropogenic CO output. One strategy is to curtail the gaseous atmospheric release by developing waste and syngas conversion technologies. Historically microorganisms have contributed to major, albeit slow, atmospheric composition changes. The current status and future potential of anaerobic gas-fermenting bacteria with special focus on acetogens are the focus of this review.

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References

Luo Y, Enghiad B, Zhao H . New tools for reconstruction and heterologous expression of natural product biosynthetic gene clusters. Nat Prod Rep. 2015; 33(2):174-82. PMC: 4742407. DOI: 10.1039/c5np00085h. View

Sakimoto K, Wong A, Yang P . Self-photosensitization of nonphotosynthetic bacteria for solar-to-chemical production. Science. 2016; 351(6268):74-7. DOI: 10.1126/science.aad3317. View

Mermelstein L, Papoutsakis E . In vivo methylation in Escherichia coli by the Bacillus subtilis phage phi 3T I methyltransferase to protect plasmids from restriction upon transformation of Clostridium acetobutylicum ATCC 824. Appl Environ Microbiol. 1993; 59(4):1077-81. PMC: 202241. DOI: 10.1128/aem.59.4.1077-1081.1993. View

Bajracharya S, Vanbroekhoven K, Buisman C, Pant D, Strik D . Application of gas diffusion biocathode in microbial electrosynthesis from carbon dioxide. Environ Sci Pollut Res Int. 2016; 23(22):22292-22308. DOI: 10.1007/s11356-016-7196-x. View

Hyman M, Arp D . Acetylene inhibition of metalloenzymes. Anal Biochem. 1988; 173(2):207-20. DOI: 10.1016/0003-2697(88)90181-9. View

Freestone T, Zhao H . Combinatorial pathway engineering for optimized production of the anti-malarial FR900098. Biotechnol Bioeng. 2015; 113(2):384-92. DOI: 10.1002/bit.25719. View

Jeschek M, Gerngross D, Panke S . Rationally reduced libraries for combinatorial pathway optimization minimizing experimental effort. Nat Commun. 2016; 7:11163. PMC: 4821882. DOI: 10.1038/ncomms11163. View

Teng L, Wang K, Xu J, Xu C . Flavin mononucleotide (FMN)-based fluorescent protein (FbFP) as reporter for promoter screening in Clostridium cellulolyticum. J Microbiol Methods. 2015; 119:37-43. DOI: 10.1016/j.mimet.2015.09.018. View

Feng X, Zhuang W, Colletti P, Tang Y . Metabolic pathway determination and flux analysis in nonmodel microorganisms through 13C-isotope labeling. Methods Mol Biol. 2012; 881:309-30. DOI: 10.1007/978-1-61779-827-6_11. View

10.

Mukherjee A, Schroeder C . Flavin-based fluorescent proteins: emerging paradigms in biological imaging. Curr Opin Biotechnol. 2014; 31:16-23. DOI: 10.1016/j.copbio.2014.07.010. View

11.

Bertsch J, Muller V . CO Metabolism in the Acetogen Acetobacterium woodii. Appl Environ Microbiol. 2015; 81(17):5949-56. PMC: 4551271. DOI: 10.1128/AEM.01772-15. View

12.

Schiel-Bengelsdorf B, Durre P . Pathway engineering and synthetic biology using acetogens. FEBS Lett. 2012; 586(15):2191-8. DOI: 10.1016/j.febslet.2012.04.043. View

13.

Nagaraju S, Davies N, Walker D, Kopke M, Simpson S . Genome editing of using CRISPR/Cas9. Biotechnol Biofuels. 2016; 9:219. PMC: 5069954. DOI: 10.1186/s13068-016-0638-3. View

14.

Kita A, Iwasaki Y, Sakai S, Okuto S, Takaoka K, Suzuki T . Development of genetic transformation and heterologous expression system in carboxydotrophic thermophilic acetogen Moorella thermoacetica. J Biosci Bioeng. 2012; 115(4):347-52. DOI: 10.1016/j.jbiosc.2012.10.013. View

15.

Kosuri S, Church G . Large-scale de novo DNA synthesis: technologies and applications. Nat Methods. 2014; 11(5):499-507. PMC: 7098426. DOI: 10.1038/nmeth.2918. View

16.

Hillson N . j5 DNA assembly design automation. Methods Mol Biol. 2014; 1116:245-69. DOI: 10.1007/978-1-62703-764-8_17. View

17.

Ungerman A, Heindel T . Carbon monoxide mass transfer for syngas fermentation in a stirred tank reactor with dual impeller configurations. Biotechnol Prog. 2007; 23(3):613-20. DOI: 10.1021/bp060311z. View

18.

Islam M, Zengler K, Edwards E, Mahadevan R, Stephanopoulos G . Investigating Moorella thermoacetica metabolism with a genome-scale constraint-based metabolic model. Integr Biol (Camb). 2015; 7(8):869-82. DOI: 10.1039/c5ib00095e. View

19.

Paddon C, Keasling J . Semi-synthetic artemisinin: a model for the use of synthetic biology in pharmaceutical development. Nat Rev Microbiol. 2014; 12(5):355-67. DOI: 10.1038/nrmicro3240. View

20.

Ueki T, Nevin K, Woodard T, Lovley D . Converting carbon dioxide to butyrate with an engineered strain of Clostridium ljungdahlii. mBio. 2014; 5(5):e01636-14. PMC: 4212834. DOI: 10.1128/mBio.01636-14. View