The New Field of 'precision Psychiatry'

Overview

Journal BMC Med

Publisher Biomed Central

Specialty General Medicine

Date 2017 Apr 14

PMID 28403846

Citations 169

Authors

Brisa S Fernandes

Leanne M Williams

Johann Steiner

Marion Leboyer

Andre F Carvalho

Michael Berk

Affiliations

Soon will be listed here.

Abstract

Background: Precision medicine is a new and important topic in psychiatry. Psychiatry has not yet benefited from the advanced diagnostic and therapeutic technologies that form an integral part of other clinical specialties. Thus, the vision of precision medicine as applied to psychiatry - 'precision psychiatry' - promises to be even more transformative than in other fields of medicine, which have already lessened the translational gap.

Discussion: Herein, we describe 'precision psychiatry' and how its several implications promise to transform the psychiatric landscape. We pay particular attention to biomarkers and to how the development of new technologies now makes their discovery possible and timely. The adoption of the term 'precision psychiatry' will help propel the field, since the current term 'precision medicine', as applied to psychiatry, is impractical and does not appropriately distinguish the field. Naming the field 'precision psychiatry' will help establish a stronger, unique identity to what promises to be the most important area in psychiatry in years to come.

Conclusion: In summary, we provide a wide-angle lens overview of what this new field is, suggest how to propel the field forward, and provide a vision of the near future, with 'precision psychiatry' representing a paradigm shift that promises to change the landscape of how psychiatry is currently conceived.

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References

Fernandes B, Gama C, Kauer-SantAnna M, Lobato M, Belmonte-de-Abreu P, Kapczinski F . Serum brain-derived neurotrophic factor in bipolar and unipolar depression: a potential adjunctive tool for differential diagnosis. J Psychiatr Res. 2009; 43(15):1200-4. DOI: 10.1016/j.jpsychires.2009.04.010. View

Collins F, Varmus H . A new initiative on precision medicine. N Engl J Med. 2015; 372(9):793-5. PMC: 5101938. DOI: 10.1056/NEJMp1500523. View

. Biomarkers and surrogate endpoints: preferred definitions and conceptual framework. Clin Pharmacol Ther. 2001; 69(3):89-95. DOI: 10.1067/mcp.2001.113989. View

Garraway L, Verweij J, Ballman K . Precision oncology: an overview. J Clin Oncol. 2013; 31(15):1803-5. DOI: 10.1200/JCO.2013.49.4799. View

Hood L, Friend S . Predictive, personalized, preventive, participatory (P4) cancer medicine. Nat Rev Clin Oncol. 2011; 8(3):184-7. DOI: 10.1038/nrclinonc.2010.227. View

Miller S, McTeague L, Gyurak A, Patenaude B, Williams L, Grieve S . COGNITION-CHILDHOOD MALTREATMENT INTERACTIONS IN THE PREDICTION OF ANTIDEPRESSANT OUTCOMES IN MAJOR DEPRESSIVE DISORDER PATIENTS: RESULTS FROM THE iSPOT-D TRIAL. Depress Anxiety. 2015; 32(8):594-604. PMC: 4841677. DOI: 10.1002/da.22368. View

Tamminga C . Approaching human neuroscience for disease understanding. World Psychiatry. 2014; 13(1):41-3. PMC: 3918015. DOI: 10.1002/wps.20099. View

Kendler K . The nature of psychiatric disorders. World Psychiatry. 2016; 15(1):5-12. PMC: 4780286. DOI: 10.1002/wps.20292. View

Korgaonkar M, Rekshan W, Gordon E, Rush A, Williams L, Blasey C . Magnetic Resonance Imaging Measures of Brain Structure to Predict Antidepressant Treatment Outcome in Major Depressive Disorder. EBioMedicine. 2015; 2(1):37-45. PMC: 4484820. DOI: 10.1016/j.ebiom.2014.12.002. View

10.

Andersson G, Titov N . Advantages and limitations of Internet-based interventions for common mental disorders. World Psychiatry. 2014; 13(1):4-11. PMC: 3918007. DOI: 10.1002/wps.20083. View

11.

Ashley E . The precision medicine initiative: a new national effort. JAMA. 2015; 313(21):2119-20. DOI: 10.1001/jama.2015.3595. View

12.

Dance A . Medical histories. Nature. 2016; 537(7619):S52-3. DOI: 10.1038/537S52a. View

13.

Garrod A . The incidence of alkaptonuria: a study in chemical individuality. 1902 [classical article]. Yale J Biol Med. 2003; 75(4):221-31. PMC: 2588790. View

14.

. Biomarkers on a roll. Nat Biotechnol. 2010; 28(5):431. DOI: 10.1038/nbt0510-431. View

15.

Goossens N, Nakagawa S, Sun X, Hoshida Y . Cancer biomarker discovery and validation. Transl Cancer Res. 2015; 4(3):256-269. PMC: 4511498. DOI: 10.3978/j.issn.2218-676X.2015.06.04. View

16.

Kitano H . Systems biology: a brief overview. Science. 2002; 295(5560):1662-4. DOI: 10.1126/science.1069492. View

17.

Tretter F, Gebicke-Haerter P . Systems biology in psychiatric research: from complex data sets over wiring diagrams to computer simulations. Methods Mol Biol. 2012; 829:567-92. DOI: 10.1007/978-1-61779-458-2_36. View

18.

Carvalho A, Kohler C, Brunoni A, Miskowiak K, Herrmann N, Lanctot K . Bias in Peripheral Depression Biomarkers. Psychother Psychosom. 2016; 85(2):81-90. DOI: 10.1159/000441457. View

19.

Perlman R, Govindaraju D . Archibald E. Garrod: the father of precision medicine. Genet Med. 2016; 18(11):1088-1089. DOI: 10.1038/gim.2016.5. View

20.

Stephan K, Bach D, Fletcher P, Flint J, Frank M, Friston K . Charting the landscape of priority problems in psychiatry, part 1: classification and diagnosis. Lancet Psychiatry. 2015; 3(1):77-83. DOI: 10.1016/S2215-0366(15)00361-2. View