Complement Components Are Expressed by Infiltrating Macrophages/Activated Microglia Early Following Viral Infection

Overview

Journal Viral Immunol

Specialties Allergy & Immunology
Microbiology

Date 2017 Apr 13

PMID 28402228

Citations 7

Authors

Jane E Libbey

Matthew F Cusick

Daniel J Doty

Robert S Fujinami

Affiliations

Soon will be listed here.

Abstract

The individual innate immune components, interleukin-6 and complement component C3, play a role in the development of acute seizures in the Theiler's murine encephalomyelitis virus-induced seizure model. We examined the mRNA expression of various other complement components, cytokines, chemokines, and major histocompatibility complex antigens both within brain and in isolated ramified microglial and infiltrating macrophage/activated microglial cell populations over a time course covering the first 3 days postinfection. We found that complement component C3 showed the greatest increase in expression in brain of all of the complement components assayed and its level of expression was higher in infiltrating macrophages/activated microglia than in ramified microglial cells.

Citing Articles

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