Human Parvovirus B19 in Patients with Beta Thalassemia Major from Tehran, Iran

Overview

Journal Blood Res

Publisher Springer Nature

Specialty Hematology

Date 2017 Apr 13

PMID 28401102

Citations 7

Authors

Seyed Ali Mohammad Arabzadeh

Farideh Alizadeh

Ahmad Tavakoli

Hamidreza Mollaei

Farah Bokharaei-Salim

Gharib Karimi

Mohammad Farahmand

Helya Sadat Mortazavi

Seyed Hamidreza Monavari

Affiliations

Soon will be listed here.

Abstract

Background: Due to the tropism of human parvovirus B19 to erythroid progenitor cells, infection in patients with an underlying hemolytic disorder such as beta-thalassemia major leads to suppression of erythrocyte formation, referred to as transient aplasia crisis (TAC), which may be life-threatening. We investigated the prevalence of parvovirus B19 among patients with beta thalassemia major attending the Zafar Adult Thalassemia Clinic in Tehran, Iran.

Methods: This cross-sectional study was performed to determine the presence of parvovirus B19 DNA in blood samples and parvovirus B19 genotypes in plasma samples of patients with thalassemia major. The population consisted of 150 patients with beta-thalassemia major who attended the Zafar clinic in Tehran. Specimens were studied using a real-time polymerase chain reaction assay.

Results: The prevalence of parvovirus B19 in our study population was 4%. Of 150 patients with thalassemia, six (4%) were positive for B19 DNA. There was no significant correlation between blood transfusion frequency and B19 DNA positivity. Finally, phylogenetic analysis of human parvovirus B19 revealed genotype I in these six patients.

Conclusion: In this study, acute B19 infections were detected in patients with beta thalassemia major. Screening of such high-risk groups can considerably reduce the incidence and prevalence of B19 infection; thus, screening is required for epidemiologic surveillance and disease-prevention measures.

Citing Articles

Molecular and serological markers of human parvovirus B19 infection in blood donors: A systematic review and meta-analysis.

Farahmand M, Tavakoli A, Ghorbani S, Monavari S, Kiani S, Minaeian S Asian J Transfus Sci. 2021; 15(2):212-222.

PMID: 34908757 PMC: 8628227. DOI: 10.4103/ajts.ajts_185_20.

A literature review on the parvovirus B19 infection in sickle cell anemia and β-thalassemia patients.

Soltani S, Zakeri A, Tabibzadeh A, Zandi M, Ershadi E, Rezayat S Trop Med Health. 2020; 48(1):96.

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Prevalence of Human Parvovirus B19 in Neurological Patients: Findings from Region of Western Saudi Arabia.

Johargy A, Jamal A, Ashgar S, Ahmed F, Kalkatawi M Curr Health Sci J. 2020; 46(1):16-22.

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Association between Parvovirus B19 and anemia in HIV-infected patients.

Nouri M, Kamakifar P, Khodabandehlou N, Nahand J, Tavakoli A, Norooznezhad F Med J Islam Repub Iran. 2020; 33:137.

PMID: 32280643 PMC: 7137816. DOI: 10.34171/mjiri.33.137.

Molecular prevalence of parvovirus B19 among HIV1-infected patients in Iran.

Kiani S, Javanmard D, Ghaffari H, Tavakoli A, Mortazavi H, Bokharaei-Salim F Med J Islam Repub Iran. 2019; 32:113.

PMID: 30815408 PMC: 6387811. DOI: 10.14196/mjiri.32.113.

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