25(OH)D Status: Effect of D Supplement

Overview

Journal Obes Sci Pract

Date 2017 Apr 11

PMID 28392936

Citations 6

Authors

J M Lukaszuk

P E Luebbers

Affiliations

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Abstract

Background: Excess adipose tissue may lead to sequestrating of vitamin D, making it less available for use in the body.

Objective: This study determined if overweight or obese individuals (BMI > 25 kg m) had insufficient (<30 ng mL) levels of 25-hydroxyvitamin D [25(OH)D] and, if so, would serum levels respond to exogenous supplementation.

Methods: Sixty-three women who were overweight/obese (BMI = 31.07 ± 5.00 kg m) were randomly assigned in a double-blind manner to receive 5,000 IU of vitamin D (D) ( = 31) or a placebo (PL) ( = 32) daily. Serum 25(OH)D concentrations were measured by finger-stick analyses at baseline and after 8 weeks of supplementation. Data were analyzed by using a 2 × 2 (group × time) repeated measure multivariate analysis of variance to determine group differences for pre-values and post-values < 0.05).

Results: On day one of the study, both D and PL groups had insufficient levels of vitamin D (mean ± SD) 24.03 ± 9.78 ng mL and 23.62 ± 9.77 ng mL, respectively. After 8 weeks of supplementation, the D group 25(OH)D level rose to a mean of 43.57 ± 10.87 ng mL ( < 0.001) versus the PL group whose 25(OH)D level remained statistically unchanged 24.31 ± 8.84 ng mL. Women who were overweight/obese had insufficient vitamin D levels prior to supplementation.

Conclusions: Following supplementation with 5,000 IU of vitamin D, all subjects' 25(OH)D levels rose to a sufficient level (≥30 ng mL). The findings of this study concur with the Institute of Medicine and Endocrine Society recommendations in that two to three times the daily requirement of vitamin D is required to improve serum vitamin D levels in individuals who are overweight or obese.

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References

Lukaszuk J, Luebbers P . 25(OH)D status: Effect of D supplement. Obes Sci Pract. 2017; 3(1):99-105. PMC: 5358080. DOI: 10.1002/osp4.85. View

Holick M . Vitamin D: a D-Lightful health perspective. Nutr Rev. 2008; 66(10 Suppl 2):S182-94. DOI: 10.1111/j.1753-4887.2008.00104.x. View

Drincic A, Armas L, Van Diest E, Heaney R . Volumetric dilution, rather than sequestration best explains the low vitamin D status of obesity. Obesity (Silver Spring). 2012; 20(7):1444-8. DOI: 10.1038/oby.2011.404. View

Bell N, Greene A, Epstein S, Oexmann M, Shaw S, Shary J . Evidence for alteration of the vitamin D-endocrine system in blacks. J Clin Invest. 1985; 76(2):470-3. PMC: 423843. DOI: 10.1172/JCI111995. View

Haines S, Park S . Vitamin D supplementation: what's known, what to do, and what's needed. Pharmacotherapy. 2012; 32(4):354-82. DOI: 10.1002/phar.1037. View

Maki K, Rubin M, Wong L, McManus J, Jensen C, Lawless A . Effects of vitamin D supplementation on 25-hydroxyvitamin D, high-density lipoprotein cholesterol, and other cardiovascular disease risk markers in subjects with elevated waist circumference. Int J Food Sci Nutr. 2011; 62(4):318-27. DOI: 10.3109/09637486.2010.536146. View

Wortsman J, Matsuoka L, Chen T, Lu Z, Holick M . Decreased bioavailability of vitamin D in obesity. Am J Clin Nutr. 2000; 72(3):690-3. DOI: 10.1093/ajcn/72.3.690. View

Lips P . Relative value of 25(OH)D and 1,25(OH)2D measurements. J Bone Miner Res. 2007; 22(11):1668-71. DOI: 10.1359/jbmr.070716. View

Wacker M, Holick M . Sunlight and Vitamin D: A global perspective for health. Dermatoendocrinol. 2014; 5(1):51-108. PMC: 3897598. DOI: 10.4161/derm.24494. View

10.

Pludowski P, Holick M, Pilz S, Wagner C, Hollis B, Grant W . Vitamin D effects on musculoskeletal health, immunity, autoimmunity, cardiovascular disease, cancer, fertility, pregnancy, dementia and mortality-a review of recent evidence. Autoimmun Rev. 2013; 12(10):976-89. DOI: 10.1016/j.autrev.2013.02.004. View

11.

Yiu Y, Yiu K, Siu C, Chan Y, Li S, Wong L . Randomized controlled trial of vitamin D supplement on endothelial function in patients with type 2 diabetes. Atherosclerosis. 2013; 227(1):140-6. DOI: 10.1016/j.atherosclerosis.2012.12.013. View

12.

Holick M, Chen T, Lu Z, Sauter E . Vitamin D and skin physiology: a D-lightful story. J Bone Miner Res. 2008; 22 Suppl 2:V28-33. DOI: 10.1359/jbmr.07s211. View

13.

Holick M . High prevalence of vitamin D inadequacy and implications for health. Mayo Clin Proc. 2006; 81(3):353-73. DOI: 10.4065/81.3.353. View

14.

Parikh S, Edelman M, Uwaifo G, Freedman R, Semega-Janneh M, Reynolds J . The relationship between obesity and serum 1,25-dihydroxy vitamin D concentrations in healthy adults. J Clin Endocrinol Metab. 2004; 89(3):1196-9. DOI: 10.1210/jc.2003-031398. View

15.

Holick M, Binkley N, Bischoff-Ferrari H, Gordon C, Hanley D, Heaney R . Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2011; 96(7):1911-30. DOI: 10.1210/jc.2011-0385. View

16.

Wamberg L, Kampmann U, Stodkilde-Jorgensen H, Rejnmark L, Pedersen S, Richelsen B . Effects of vitamin D supplementation on body fat accumulation, inflammation, and metabolic risk factors in obese adults with low vitamin D levels - results from a randomized trial. Eur J Intern Med. 2013; 24(7):644-9. DOI: 10.1016/j.ejim.2013.03.005. View

17.

Dawson-Hughes B, Heaney R, Holick M, Lips P, Meunier P, Vieth R . Estimates of optimal vitamin D status. Osteoporos Int. 2005; 16(7):713-6. DOI: 10.1007/s00198-005-1867-7. View

18.

Ananthakrishnan A, Khalili H, Higuchi L, Bao Y, Korzenik J, Giovannucci E . Higher predicted vitamin D status is associated with reduced risk of Crohn's disease. Gastroenterology. 2011; 142(3):482-9. PMC: 3367959. DOI: 10.1053/j.gastro.2011.11.040. View

19.

Ekwaru J, Zwicker J, Holick M, Giovannucci E, Veugelers P . The importance of body weight for the dose response relationship of oral vitamin D supplementation and serum 25-hydroxyvitamin D in healthy volunteers. PLoS One. 2014; 9(11):e111265. PMC: 4220998. DOI: 10.1371/journal.pone.0111265. View

20.

Harris S, Pittas A, Palermo N . A randomized, placebo-controlled trial of vitamin D supplementation to improve glycaemia in overweight and obese African Americans. Diabetes Obes Metab. 2012; 14(9):789-94. DOI: 10.1111/j.1463-1326.2012.01605.x. View