Inflammatory and Oxidative Stress Markers in Experimental Allergic Asthma

Overview

Journal Inflammation

Specialties Allergy & Immunology
Pathology

Date 2017 Apr 10

PMID 28391514

Citations 9

Authors

Renata Tiscoski Nesi

Emanuel Kennedy-Feitosa

Manuella Lanzetti

Mariana Barcellos Avila

Clarissa Bichara Magalhaes

Walter Araujo Zin

Debora Souza Faffe

Luis Cristovao Porto

Samuel Santos Valenca

Affiliations

Soon will be listed here.

Abstract

Ovalbumin-induced allergic lung inflammation (ALI) is a condition believed to be mediated by cytokines, extracellular matrix remodeling, and redox imbalance. In this study, we evaluated pulmonary function together with inflammatory markers as interleukin-4 (IL-4), myeloperoxidase (MPO), eosinophil cells, and redox markers in the lungs of BALB/c mice after ovalbumin (OVA) sensitization and challenge. Our results showed an increase in bronchial hyperresponsiveness stimulated by methacholine (Mch), inflammatory cell influx, especially eosinophils together with an increase of high mobility group box 1 (HMGB1) and altered lipid peroxidation (LP) and antioxidant defenses in the OVA group compared to the control group (p ≤ 0.5). Thus, we demonstrated that OVA-induced ALI altered redox status concomitantly with impaired lung function, which was associated with HMGB1 expression and proteolytic remodeling. Taken together all results found here, we may suggest HMGB1 is an important therapeutic target for asthma, once orchestrates the redox signaling, inflammation, and remodeling that contribute to the disease development.

Citing Articles

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