Concise Review: Stem Cells in Osteoimmunology

Overview

Journal Stem Cells

Publisher Oxford University Press

Specialties Cell Biology
Reproductive Medicine

Date 2017 Apr 9

PMID 28390147

Citations 27

Authors

Fernando A Fierro

Jan A Nolta

Iannis E Adamopoulos

Affiliations

Soon will be listed here.

Abstract

Bone remodeling is a lifelong process in which mature bone tissue is removed from the skeleton by bone resorption and is replenished by new during ossification or bone formation. The remodeling cycle requires both the differentiation and activation of two cell types with opposing functions; the osteoclast, which orchestrates bone resorption, and the osteoblast, which orchestrates bone formation. The differentiation of these cells from their respective precursors is a process which has been overshadowed by enigma, particularly because the precise osteoclast precursor has not been identified and because the identification of skeletal stem cells, which give rise to osteoblasts, is very recent. Latest advances in the area of stem cell biology have enabled us to gain a better understanding of how these differentiation processes occur in physiological and pathological conditions. In this review we postulate that modulation of stem cells during inflammatory conditions is a necessary prerequisite of bone remodeling and therefore an essential new component to the field of osteoimmunology. In this context, we highlight the role of transcription factor nuclear factor of activated T cells cytoplasmic 1 (NFATc1), because it directly links inflammation with differentiation of osteoclasts and osteoblasts. Stem Cells 2017;35:1461-1467.

Citing Articles

Remodeling periodontal osteoimmune microenvironment through MAPK/NFκB phosphorylation pathway of macrophage via intelligent ROS scavenging.

Qiu X, Peng H, Zhao Y, Yu Y, Yang J, Liu C Hum Cell. 2023; 36(6):1991-2005.

PMID: 37695495 DOI: 10.1007/s13577-023-00979-3.

Innate immune memory in inflammatory arthritis.

Jeljeli M, Adamopoulos I Nat Rev Rheumatol. 2023; 19(10):627-639.

PMID: 37674048 PMC: 10721491. DOI: 10.1038/s41584-023-01009-0.

Molecular Basis beyond Interrelated Bone Resorption/Regeneration in Periodontal Diseases: A Concise Review.

Sadek K, El Moshy S, Radwan I, Rady D, Abbass M, El-Rashidy A Int J Mol Sci. 2023; 24(5).

PMID: 36902030 PMC: 10003253. DOI: 10.3390/ijms24054599.

A Review of Biomimetic and Biodegradable Magnetic Scaffolds for Bone Tissue Engineering and Oncology.

Paltanea G, Manescu Paltanea V, Antoniac I, Antoniac A, Nemoianu I, Robu A Int J Mol Sci. 2023; 24(5).

PMID: 36901743 PMC: 10001544. DOI: 10.3390/ijms24054312.

Mesenchymal stem cell-derived extracellular vesicles, osteoimmunology and orthopedic diseases.

Ma M, Cui G, Liu Y, Tang Y, Lu X, Yue C PeerJ. 2023; 11:e14677.

PMID: 36710868 PMC: 9881470. DOI: 10.7717/peerj.14677.

References

Massberg S, Schaerli P, Knezevic-Maramica I, Kollnberger M, Tubo N, Moseman E . Immunosurveillance by hematopoietic progenitor cells trafficking through blood, lymph, and peripheral tissues. Cell. 2007; 131(5):994-1008. PMC: 2330270. DOI: 10.1016/j.cell.2007.09.047. View

Owen M, FRIEDENSTEIN A . Stromal stem cells: marrow-derived osteogenic precursors. Ciba Found Symp. 1988; 136:42-60. DOI: 10.1002/9780470513637.ch4. View

Crisan M, Chen C, Corselli M, Andriolo G, Lazzari L, Peault B . Perivascular multipotent progenitor cells in human organs. Ann N Y Acad Sci. 2009; 1176:118-23. DOI: 10.1111/j.1749-6632.2009.04967.x. View

Reinders M, De Fijter J, Roelofs H, Bajema I, de Vries D, Schaapherder A . Autologous bone marrow-derived mesenchymal stromal cells for the treatment of allograft rejection after renal transplantation: results of a phase I study. Stem Cells Transl Med. 2013; 2(2):107-11. PMC: 3659754. DOI: 10.5966/sctm.2012-0114. View

Chen G, Deng C, Li Y . TGF-β and BMP signaling in osteoblast differentiation and bone formation. Int J Biol Sci. 2012; 8(2):272-88. PMC: 3269610. DOI: 10.7150/ijbs.2929. View

Park D, Spencer J, Koh B, Kobayashi T, Fujisaki J, Clemens T . Endogenous bone marrow MSCs are dynamic, fate-restricted participants in bone maintenance and regeneration. Cell Stem Cell. 2012; 10(3):259-72. PMC: 3652251. DOI: 10.1016/j.stem.2012.02.003. View

Adamopoulos I, Tessmer M, Chao C, Adda S, Gorman D, Petro M . IL-23 is critical for induction of arthritis, osteoclast formation, and maintenance of bone mass. J Immunol. 2011; 187(2):951-9. PMC: 3896980. DOI: 10.4049/jimmunol.1003986. View

Mossadegh-Keller N, Sarrazin S, Kandalla P, Espinosa L, Stanley E, Nutt S . M-CSF instructs myeloid lineage fate in single haematopoietic stem cells. Nature. 2013; 497(7448):239-43. PMC: 3679883. DOI: 10.1038/nature12026. View

Caetano-Lopes J, Canhao H, Fonseca J . Osteoimmunology--the hidden immune regulation of bone. Autoimmun Rev. 2008; 8(3):250-5. DOI: 10.1016/j.autrev.2008.07.038. View

10.

Aliprantis A, Ueki Y, Sulyanto R, Park A, Sigrist K, Sharma S . NFATc1 in mice represses osteoprotegerin during osteoclastogenesis and dissociates systemic osteopenia from inflammation in cherubism. J Clin Invest. 2008; 118(11):3775-89. PMC: 2564610. DOI: 10.1172/JCI35711. View

11.

Komori T, Yagi H, Nomura S, Yamaguchi A, Sasaki K, Deguchi K . Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts. Cell. 1997; 89(5):755-64. DOI: 10.1016/s0092-8674(00)80258-5. View

12.

Boyle W, Simonet W, Lacey D . Osteoclast differentiation and activation. Nature. 2003; 423(6937):337-42. DOI: 10.1038/nature01658. View

13.

Chen J, Miyanishi M, Wang S, Yamazaki S, Sinha R, Kao K . Hoxb5 marks long-term haematopoietic stem cells and reveals a homogenous perivascular niche. Nature. 2016; 530(7589):223-7. PMC: 4854608. DOI: 10.1038/nature16943. View

14.

Ding L, Saunders T, Enikolopov G, Morrison S . Endothelial and perivascular cells maintain haematopoietic stem cells. Nature. 2012; 481(7382):457-62. PMC: 3270376. DOI: 10.1038/nature10783. View

15.

Arinobu Y, Mizuno S, Chong Y, Shigematsu H, Iino T, Iwasaki H . Reciprocal activation of GATA-1 and PU.1 marks initial specification of hematopoietic stem cells into myeloerythroid and myelolymphoid lineages. Cell Stem Cell. 2008; 1(4):416-27. DOI: 10.1016/j.stem.2007.07.004. View

16.

Greenbaum A, Hsu Y, Day R, Schuettpelz L, Christopher M, Borgerding J . CXCL12 in early mesenchymal progenitors is required for haematopoietic stem-cell maintenance. Nature. 2013; 495(7440):227-30. PMC: 3600148. DOI: 10.1038/nature11926. View

17.

Crisan M, Yap S, Casteilla L, Chen C, Corselli M, Park T . A perivascular origin for mesenchymal stem cells in multiple human organs. Cell Stem Cell. 2008; 3(3):301-13. DOI: 10.1016/j.stem.2008.07.003. View

18.

FRIEDENSTEIN A, Chailakhjan R, LALYKINA K . The development of fibroblast colonies in monolayer cultures of guinea-pig bone marrow and spleen cells. Cell Tissue Kinet. 1970; 3(4):393-403. DOI: 10.1111/j.1365-2184.1970.tb00347.x. View

19.

Alnaeeli M, Penninger J, Teng Y . Immune interactions with CD4+ T cells promote the development of functional osteoclasts from murine CD11c+ dendritic cells. J Immunol. 2006; 177(5):3314-26. DOI: 10.4049/jimmunol.177.5.3314. View

20.

Morrison S, Weissman I . The long-term repopulating subset of hematopoietic stem cells is deterministic and isolatable by phenotype. Immunity. 1994; 1(8):661-73. DOI: 10.1016/1074-7613(94)90037-x. View